sirop

DRUG3 trials

Sponsors

Centre Hospitalier Universitaire De Nantes, Astrazeneca AB, Amsterdam UMC Stichting

Conditions

Advanced/metastatic solid tumors that are MTAP deficient.Confirmed diagnosis of Alcoholic liver cirrhosisPost-operative pain after surgery

Phase 1

PRIMROSE: A Modular Phase I/IIa, Multi-centre, Dose Escalation, and Expansion Study of AZD3470, a MTA Cooperative PRMT5 Inhibitor, as Monotherapy and in Combination with Anticancer Agents in Patients with Advanced/Metastatic Solid Tumours That are MTAP Deficient

RecruitingCTIS2023-506757-38-00

Astrazeneca ABAdvanced/metastatic solid tumors that are MTAP deficient.

Start: 2024-11-27Target: 40Updated: 2025-09-02

Phase 4

Avoid With locoregional Analgesia Persistant Postoperative Pain After Surgery In Children

RecruitingCTIS2023-503499-25-00

Centre Hospitalier Universitaire De NantesPost-operative pain after surgery

Start: 2024-06-06Target: 222Updated: 2024-10-11

The PEARL trial: Prevention of hepatic Encephalopathy by administration of Rifaximin and Lactulose in patients with liver cirrhosis undergoing placement of a transjugular intrahepatic portosystemic shunt: a multi-centre randomized, double blind, placebo controlled trial.

Not yet recruitingCTIS2024-512040-28-01

Amsterdam UMC StichtingConfirmed diagnosis of Alcoholic liver cirrhosis

Target: 91Updated: 2024-11-06