Sirolimus 0.5 mg

DRUG2 trials

Sponsors

Rare Partners srl Impresa Sociale, Università degli Studi di Ferrara

Conditions

Beta-Thalassemia

Phase 2

Testing SIROLIMUS in Beta-thalassemia Transfusion Dependent Patients

CompletedNCT03877809

Rare Partners srl Impresa SocialeBeta-Thalassemia

Start: 2019-06-27End: 2022-04-30Updated: 2024-01-23

Testing SIROLIMUS in Beta-thalassemia Transfusion Dependent Patients (THALA-RAP)

Università degli Studi di FerraraBeta-Thalassemia

Start: 2021-04-13End: 2022-04-30Target: 45Updated: 2021-11-12

Related Papers

Co-Induction of ULK-1 and AHSP mRNAs in Erythroid Precursor Cells Isolated From a Sirolimus-Treated β-Thalassemia Patient: A Case Report Study

British Journal of Biomedical Science2025-06-27

Increased Expression of α-Hemoglobin Stabilizing Protein (AHSP) mRNA in Erythroid Precursor Cells Isolated from β-Thalassemia Patients Treated with Sirolimus (Rapamycin)

Journal of Clinical Medicine2024-04-244 citations

Decrease in α-Globin and Increase in the Autophagy-Activating Kinase ULK1 mRNA in Erythroid Precursors from β-Thalassemia Patients Treated with Sirolimus

International Journal of Molecular Sciences2023-10-108 citations

Effects of Sirolimus Treatment on Fetal Hemoglobin Production and Response to SARS-CoV-2 Vaccination: A Case Report Study

Hematology Reports2023-07-12

5613423 TREATMENT OF ERYTHROID PRECURSOR CELLS FROM β-THALASSEMIC PATIENTS WITH ISOXAZOLE DERIVATIVES: POTENT INDUCTION OF FETAL HEMOGLOBIN

HemaSphere2023-04-01

5613398 A DRUG REPOSITIONING PROJECT FOR Β-THALASSEMIA: SIROLIMUS AND CINCHONA ALKALOIDS

HemaSphere2023-04-01

Effects of Sirolimus treatment on patients with <scp>β‐Thalassemia</scp>: Lymphocyte immunophenotype and biological activity of memory <scp>CD4</scp><sup>+</sup> and <scp>CD8</scp><sup>+</sup> T cells

Journal of Cellular and Molecular Medicine2023-01-1010 citations

Expression of γ-globin genes in β-thalassemia patients treated with sirolimus: results from a pilot clinical trial (Sirthalaclin)

Therapeutic Advances in Hematology2022-01-0127 citations