Sirolimus (Rapamune®)

DRUG4 trials

Sponsors

Wyeth is now a wholly owned subsidiary of Pfizer, Peking Union Medical College Hospital, Ain Shams University, Massachusetts General Hospital

Conditions

Aplastic AnaemiaOrbital Lymphatic MalformationPost-hemorrhagic Hydrocephalus (PHH)Renal Transplant

Phase 1

Ventricular mTOR Inhibition to Prevent Hydrocephalus After Brain Hemorrhage

Not yet recruitingNCT07662174

Massachusetts General HospitalPost-hemorrhagic Hydrocephalus (PHH)

Start: 2027-01-01End: 2027-12-31Target: 15Updated: 2026-06-25

Phase 2

Efficacy and Safety of Sirolimus With or Without Cyclosporin A in Chinese Patients With Aplastic Anemia Refractory/Intolerant to Cyclosporin A

RecruitingNCT06802055

Peking Union Medical College HospitalAplastic Anaemia

Start: 2025-01-25End: 2027-01-31Target: 40Updated: 2025-06-04

Phase 3

Study Evaluating Rapamune® Maintenance Regimen

CompletedNCT00478608

Wyeth is now a wholly owned subsidiary of PfizerRenal Transplant

Start: 2007-03-31End: 2008-11-30Updated: 2010-04-28

Systematic Approach for Children With Orbital Malformation With Sirolimus Use

RecruitingNCT07378657

Ain Shams UniversityOrbital Lymphatic Malformation

Start: 2025-11-01End: 2027-11-01Target: 30Updated: 2026-01-30