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SIR-Spheres

DEVICE6 trials

Sponsors

Singapore Clinical Research Institute, Singapore General Hospital, M.D. Anderson Cancer Center, SCRI Development Innovations, LLC, Roger Williams Medical Center

Conditions

Advanced CancersColorectal NeoplasmsHepatocellular CarcinomaLiver Metastases

Phase 1

Study of SIR-Spheres Plus Sorafenib as 1st Line Treatment for Non-resectable Primary Hepatocellular Carcinoma (HCC)
CompletedNCT00712790
Singapore Clinical Research InstituteHepatocellular Carcinoma
Start: 2008-06-30End: 2014-04-30Updated: 2016-01-06
Phase 1 Trial With SIR-Spheres and Cetuximab +/- Erlotinib
WithdrawnNCT01432119
M.D. Anderson Cancer CenterAdvanced Cancers
Start: 2012-12-31Updated: 2013-04-09
CAR-T Hepatic Artery Infusions and Sir-Spheres for Liver Metastases
CompletedNCT02416466
Roger Williams Medical CenterLiver Metastases
Start: 2015-04-30End: 2018-06-30Updated: 2019-03-26

Phase 2

Safety Study of Regorafenib and SIR-Spheres® Microspheres Radioembolization in Patients With Refractory Metastatic Colorectal Cancer With Liver Metastases
CompletedNCT02195011
SCRI Development Innovations, LLCColorectal Neoplasms
Start: 2014-07-31End: 2017-06-04Updated: 2023-12-05
A Study of the Safety and Antitumoral Efficacy of Nivolumab After SIRT for the Treatment of Patients With HCC
CompletedNCT03380130
Clinica Universidad de Navarra, Universidad de NavarraHepatocellular Carcinoma
Start: 2017-09-11End: 2020-11-04Updated: 2020-11-04

Phase 3

Study to Compare Selective Internal Radiation Therapy (SIRT) Versus Sorafenib in Locally Advanced Hepatocellular Carcinoma (HCC)
NCT01135056
Singapore General HospitalHepatocellular Carcinoma
Start: 2010-07-31End: 2018-07-31Updated: 2018-04-24

Related Papers

Health-related quality of life in patients with unresectable hepatocellular carcinoma treated with SIRT and nivolumab: a sub-analysis of the NASIR-HCC trial
Journal of Patient-Reported Outcomes2025-04-081 citations
Nivolumab after selective internal radiation therapy for the treatment of hepatocellular carcinoma: a phase 2, single-arm study
Journal for ImmunoTherapy of Cancer2022-11-0168 citations
Hepatic Flow Redistribution is Feasible in Patients with Hepatic Malignancies Undergoing Same-Day Work-Up Angiography and Yttrium-90 Microsphere Radioembolization.
2019-12-177 citations
Abstract CT109: HITM-SIR: Phase Ib trial of CAR-T hepatic artery infusions and selective internal radiation therapy for liver metastases
Cancer Research2017-07-017 citations
Phase III multi-centre open-label randomized controlled trial of selective internal radiation therapy (SIRT) versus sorafenib in locally advanced hepatocellular carcinoma: The SIRveNIB study.
Journal of Clinical Oncology2017-05-2059 citations
Safety analysis of regorafenib prior to selective internal radiation therapy (SIRT) using <sup>90</sup>Y resin microspheres for the treatment (tx) of patients (pts) with refractory metastatic colorectal cancer (mCRC) with liver metastases (mets).
Journal of Clinical Oncology2017-05-20
VESPRO: An Individual Patient Data Prospective Meta-Analysis of Selective Internal Radiation Therapy Versus Sorafenib for Advanced, Locally Advanced, or Recurrent Hepatocellular Carcinoma of the SARAH and SIRveNIB Trials
JMIR Research Protocols2017-02-1511 citations
Single administration of Selective Internal Radiation Therapy versus continuous treatment with sorafeNIB in locally advanced hepatocellular carcinoma (SIRveNIB): study protocol for a phase iii randomized controlled trial.
2016-11-0720 citations
Radioembolisation with yttrium‒90 microspheres versus sorafenib for treatment of advanced hepatocellular carcinoma (SARAH): study protocol for a randomised controlled trial.
2014-12-0336 citations
Multicenter Phase II Study of Sequential Radioembolization-Sorafenib Therapy for Inoperable Hepatocellular Carcinoma
PLoS ONE2014-03-1067 citations