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sIPV

BIOLOGICAL11 trials

Sponsors

Janssen Vaccines & Prevention B.V., Jiangsu Province Centers for Disease Control and Prevention, China National Biotec Group Company Limited, Sinovac Biotech Co., Ltd, Institute of Medical Biology, Chinese Academy of Medical Sciences

Conditions

Diphteria, Tetanus and PertussisHealthyMMR VaccinePolioPoliomyelitisVaccinationVaccine

Phase 1

A First in Human Study to Assess the Safety, Tolerability and Immunogenicity of a Single Dose of a Trivalent Inactivated Poliovirus Vaccine Based on Sabin Strains (sIPV) Given Intramuscularly in Healthy Adults
CompletedNCT03032588
Janssen Vaccines & Prevention B.V.Healthy
Start: 2017-10-09End: 2018-05-18Updated: 2025-02-03
Safety and Immunogenicity of a Sabin Inactivated Poliovirus Vaccine
CompletedNCT04264598
Jiangsu Province Centers for Disease Control and PreventionPolio
Start: 2017-08-21End: 2018-12-28Updated: 2020-02-11
Safety and Immunogenicity of a Sabin Inactivated Poliovirus Vaccine (Phase Ib)
CompletedNCT04264546
Jiangsu Province Centers for Disease Control and PreventionPolio
Start: 2017-11-24End: 2018-12-28Updated: 2020-02-11

Phase 2

A Study to Assess the Safety, Reactogenicity and Immunogenicity of a Trivalent Inactivated Poliovirus Vaccine (IPV) Based on Sabin Strains Compared to Conventional Salk IPV in a 6, 10 and 14 Weeks of Age Immunization Schedule
CompletedNCT03566940
Janssen Vaccines & Prevention B.V.Healthy
Start: 2018-07-31End: 2019-10-17Updated: 2025-02-03

Phase 3

Phase III Clinical Trial of Sabin Strain Inactivated Poliovirus Vaccine (Vero Cell)
CompletedNCT07297186
Beijing Minhai Biotechnology Co., LtdPoliomyelitis
Start: 2017-08-21End: 2023-04-10Updated: 2025-12-22

Phase 4

Evaluation of Safety and Immunogenicity of Combined Immunization of sIPV, DTaP and HepA
NCT04636827
China National Biotec Group Company LimitedVaccination
Start: 2020-11-11End: 2021-12-31Target: 600Updated: 2020-11-19
Evaluation of Immunogenicity and Safety of Combined Immunization of sIPV, DTaP and MMR
NCT04638985
China National Biotec Group Company LimitedVaccine
Start: 2020-11-13End: 2021-12-31Target: 600Updated: 2020-12-10
Sequential Vaccination of Poliomyelitis Vaccine (Vero Cells), Inactivated, Sabin Strains From Different Manufacturers
CompletedNCT06346834
Sinovac Biotech Co., LtdPoliomyelitis
Start: 2024-05-20End: 2024-12-06Updated: 2025-03-14
Booster Dose of sIPV Co-administered With MMR and HepA-I.
CompletedNCT06442449
Sinovac Biotech Co., LtdPoliomyelitis
Start: 2024-08-08End: 2025-10-10Updated: 2026-01-16
Study of Concomitant Administration of the sIPV and DTaP or MMR
Not yet recruitingNCT06920069
Institute of Medical Biology, Chinese Academy of Medical SciencesDiphteria, Tetanus and Pertussis, MMR Vaccine, Polio
Start: 2025-05-15End: 2031-06-15Target: 2640Updated: 2025-04-17
Phase IV Clinical Study of sIPV Administration in Adolescent and Adult Populations
RecruitingNCT07354269
Sinovac Biotech Co., LtdPoliomyelitis
Start: 2025-09-26End: 2026-05-02Target: 180Updated: 2026-01-21

Related Papers

Immunogenicity and safety of co-administration of sabin-strain-based inactivated poliovirus vaccine, diphtheria-tetanus-acellular pertussis vaccine, and live attenuated hepatitis A vaccine in 18-month-old children: A multicenter randomized controlled non-inferiority trial in China.
2025-10-27
Immunogenicity and Safety of Sabin Strain Inactivated Poliovirus Vaccine Booster Dose Administered Separately or Concomitantly with Inactivated Hepatitis A Vaccine or Measles-Mumps-Rubella Combined Attenuated Live Vaccine: An Open-Labelled, Randomized, Controlled, Phase 4 Clinical Trial.
2025-10-23
Safety and immunogenicity of a new Sabin inactivated poliovirus vaccine candidate produced on the PER.C6® cell-line: a phase 1 randomized controlled trial in adults
Human Vaccines & Immunotherapeutics2020-11-117 citations
The effect of maternal poliovirus antibodies on the immune responses of infants to poliovirus vaccines.
2020-08-316 citations