Simufilam
Sponsors
Cassava Sciences, Inc.
Conditions
AbsorptionAlzheimer DiseaseAlzheimer's DiseaseExcretionHealthy VolunteersHepatic InsufficiencyMetabolism
Phase 1
Food Effect and Bioequivalence Study of Simufilam Tablets in Healthy Volunteers
CompletedNCT04932655
Start: 2021-05-04End: 2021-05-11Updated: 2023-08-22
Open-label Study of the Absorption, Metabolism, and Excretion of [14C]-Simufilam Following a Single Oral Dose in Healthy Male Subjects
CompletedNCT06195319
Start: 2024-02-07End: 2024-03-27Updated: 2025-03-20
A Pharmacokinetic Study of Simufilam in Subjects With Impaired Hepatic Function
CompletedNCT06390410
Start: 2024-06-26End: 2024-12-07Updated: 2025-01-07
Phase 2
Phase 3
Simufilam 100 mg for Mild-to-Moderate Alzheimer's Disease
CompletedNCT04994483
Start: 2021-11-03End: 2024-10-02Updated: 2025-05-25
Simufilam 50 mg or 100 mg for Mild-to-Moderate Alzheimer's Disease
TerminatedNCT05026177
Start: 2021-11-18End: 2024-12-30Updated: 2025-09-22
Open-label Extension for Phase 3 Clinical Trials of Simufilam
TerminatedNCT05575076
Start: 2022-11-07End: 2025-01-31Updated: 2025-05-23