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Simtuzumab

BIOLOGICAL8 trials

Sponsors

Gilead Sciences

Conditions

Colorectal CancerHIVHIV/HCV Co-infectionHepatitis CIdiopathic Pulmonary FibrosisLiver FibrosisMyelofibrosisPancreatic Cancer

Phase 2

Efficacy and Safety of Simtuzumab in Adults With Primary, Post Polycythemia Vera or Post Essential Thrombocythemia Myelofibrosis
CompletedNCT01369498
Gilead SciencesMyelofibrosis
Start: 2011-06-30End: 2014-09-24Updated: 2020-07-01
Pilot Study of Simtuzumab in the Treatment of Liver Fibrosis
CompletedNCT01452308
Gilead SciencesLiver Fibrosis
Start: 2011-11-30End: 2013-08-31Updated: 2014-02-03
A Study to Evaluate the Efficacy and Safety of Simtuzumab Combined With Gemcitabine for Metastatic Pancreatic Adenocarcinoma
CompletedNCT01472198
Gilead SciencesPancreatic Cancer
Start: 2011-11-30End: 2015-02-28Updated: 2015-03-10
Efficacy and Safety of Simtuzumab (SIM) With FOLFIRI as Second Line Treatment in Colorectal Adenocarcinoma
TerminatedNCT01479465
Gilead SciencesColorectal Cancer
Start: 2011-12-31End: 2015-02-28Updated: 2019-04-17
Simtuzumab (GS-6624) in the Prevention of Progression of Liver Fibrosis in Adults With Primary Sclerosing Cholangitis (PSC)
CompletedNCT01672853
Gilead SciencesPrimary Sclerosing Cholangitis (PSC)
Start: 2013-03-04End: 2016-08-24Updated: 2019-10-22
Study of Simtuzumab in HIV and/or Hepatitis C- Infected Adults With Liver Fibrosis
CompletedNCT01707472
Gilead SciencesHepatitis C, HIV, HIV/HCV Co-infection +1
Start: 2012-10-04End: 2014-10-17Updated: 2019-11-05
Long-Term Safety Study of GS-6624 in Adults With Idiopathic Pulmonary Fibrosis (IPF)
TerminatedNCT01759511
Gilead SciencesIdiopathic Pulmonary Fibrosis
Start: 2012-10-18End: 2016-02-19Updated: 2017-04-04
Study to Assess the Efficacy and Safety of Simtuzumab (GS-6624) in Adults With Idiopathic Pulmonary Fibrosis (IPF)
TerminatedNCT01769196
Gilead SciencesIdiopathic Pulmonary Fibrosis
Start: 2013-01-31End: 2016-02-23Updated: 2017-05-30

Related Papers

Liver transcriptome analysis reveals PSC-attributed gene set associated with fibrosis progression.
2024-11-123 citations
AI-based automation of enrollment criteria and endpoint assessment in clinical trials in liver diseases.
2024-08-0728 citations
Serologic extracellular matrix remodeling markers are related to fibrosis stage and prognosis in a phase 2b trial of simtuzumab in patients with primary sclerosing cholangitis
Hepatology Communications2024-07-017 citations
An adjudication algorithm for respiratory-related hospitalisation in idiopathic pulmonary fibrosis
ERJ Open Research2024-01-013 citations
Magnetic Resonance Elastography Shear Wave Velocity Correlates with Liver Fibrosis and Hepatic Venous Pressure Gradient in Adults with Advanced Liver Disease
BioMed Research International2017-01-0146 citations
Efficacy of simtuzumab versus placebo in patients with idiopathic pulmonary fibrosis: a randomised, double-blind, controlled, phase 2 trial.
2016-12-07203 citations
A phase II, randomized, double-blinded, placebo-controlled study of simtuzumab or placebo in combination with FOLFIRI for the second line treatment of metastatic KRAS mutant colorectal adenocarcinoma.
Journal of Clinical Oncology2015-05-205 citations