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Short course radiotherapy

RADIATION18 trials

Sponsors

Trans Tasman Radiation Oncology Group, International Atomic Energy Agency, Yonsei University, Korea Cancer Center Hospital, Chinese Academy of Medical Sciences

Conditions

Adenocarcinoma of RectumAdenocarcinoma of the RectumBiliary Tract Tumors, Gastric Cancer, Small Cell Lung CancerCentral Nervous System CancerColorectal CancerEsophageal CancerLDRTLiver Metastasis

Phase 1

LDRT Combined With Immunochemotherapy for Colorectal Cancer With Liver Metastasis
RecruitingNCT06848465
Daping Hospital and the Research Institute of Surgery of the Third Military Medical UniversityColorectal Cancer, LDRT, Liver Metastasis
Start: 2025-02-28End: 2027-11-30Target: 9Updated: 2026-04-03

Phase 2

A Trial of Neoadjuvant FOLFOX6 With Short Course Radiotherapy in Patients With Unresectable Rectal Cancer and Liver Metastasis
CompletedNCT01269229
Yonsei UniversityRectal Cancer
Start: 2010-01-31End: 2015-04-30Updated: 2016-09-07
Short Course Radiotherapy Followed Intensive Chemotherapy With Delayed Surgery for Rectal Cancer With Synchronous Distant Metastasis
NCT01923987
Korea Cancer Center HospitalLiver Metastasis, Lung Metastasis, Rectal Cancer
Start: 2012-08-31End: 2022-12-31Target: 39Updated: 2019-09-20
Short Course Radiotherapy Combined With Chemotherapy in Stage IV Rectal Cancer With Resectable Liver Metastases
NCT02510378
Chinese Academy of Medical SciencesStage IV Rectal Cancer, Liver Metastasis, Resectable
Start: 2014-01-31End: 2022-12-31Target: 47Updated: 2015-07-29
Can We Save the Rectum by Watchful Waiting or TransAnal Surgery Following (chemo)Radiotherapy Versus Total Mesorectal Excision for Early REctal Cancer?
Active, not recruitingNCT02945566
University of BirminghamAdenocarcinoma of the Rectum
Start: 2017-06-14End: 2028-08-31Target: 380Updated: 2025-03-27
Study of Surufatinib Combined With Sintilimab and SCRT in Advanced Solid Tumors
NCT05527821
Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyBiliary Tract Tumors, Gastric Cancer, Small Cell Lung Cancer, Unresectable Advanced Solid Tumors
Start: 2022-09-30End: 2025-09-30Target: 36Updated: 2022-09-06
SCRT(Short Course Radiotherapy) Combined With CAPOX Plus QL1706 for Rectal Cancer Liver Metastases
RecruitingNCT06787183
Fujian Cancer HospitalLocally Advanced Rectal Cancer With Liver Metastases
Start: 2025-12-01End: 2029-12-01Target: 42Updated: 2026-03-03

Phase 3

A Randomised Trial of Preoperative Radiotherapy for Stage T3 Adenocarcinoma of Rectum
CompletedNCT00145769
Trans Tasman Radiation Oncology GroupAdenocarcinoma of Rectum
Start: 2001-07-31End: 2011-05-31Updated: 2013-08-09
Palliative Radiotherapy and Brachytherapy for Oesophageal Cancer Dysphagia
CompletedNCT00665197
International Atomic Energy AgencyEsophageal Cancer
Start: 2007-02-28End: 2011-02-28Updated: 2011-10-13
Study Evaluating Two Treatment Strategies for Rectal Cancer in Patients ≥75 Years Old
Not yet recruitingNCT07118800
UNICANCERLocally Advanced Rectal Adenocarcinoma
Start: 2025-12-15End: 2032-01-15Target: 160Updated: 2025-08-12

Unknown Phase

Short Course Radiation Therapy in Palliative Treatment
CompletedNCT03196700
IRCCS Azienda Ospedaliero-Universitaria di BolognaPalliative Care
Start: 2009-01-01End: 2017-06-01Updated: 2017-06-23
Short Course Radiotherapy in Complicated Bone Metastases Palliation
CompletedNCT03455231
IRCCS Azienda Ospedaliero-Universitaria di BolognaPalliative Care
Start: 2009-01-01End: 2017-01-01Updated: 2018-03-12
Palliative Short Course Radiotherapy for Advanced Thoracic Cancer
CompletedNCT03465553
IRCCS Azienda Ospedaliero-Universitaria di BolognaPalliative Care
Start: 2009-01-01End: 2018-01-01Updated: 2018-03-14
2D-radiotherapy in Palliation of Advanced Esophageal Cancer
CompletedNCT03922152
IRCCS Azienda Ospedaliero-Universitaria di BolognaPalliative Care
Start: 2009-01-01End: 2019-01-01Updated: 2019-09-16
Radiotherapy in Palliation of Advanced Pelvic Cancer
CompletedNCT03947268
IRCCS Azienda Ospedaliero-Universitaria di BolognaPalliative Care
Start: 2009-01-01End: 2019-01-01Updated: 2019-05-14
Efficacy and Safety of Conventional Neoadjuvant Therapy Versus Total Neoadjuvant Therapy in Older Patients With Locally Advanced Rectal Cancer
RecruitingNCT06052332
Jules Bordet InstituteLocally Advanced Rectal Cancer, Older People
Start: 2024-02-07End: 2033-12-31Target: 230Updated: 2025-12-05
The Role of Short Course of Palliative Radiation in Metastatic Cancer Rectum
Not yet recruitingNCT06521827
Assiut UniversityMetastatic Cancer Rectum
Start: 2024-08-31End: 2026-12-31Target: 49Updated: 2024-07-26
Short Course Radiotherapy
Not yet recruitingNCT07147179
Abramson Cancer Center at Penn MedicineCentral Nervous System Cancer
Start: 2026-02-01End: 2027-03-01Target: 15Updated: 2026-01-22

Related Papers

A phase Ib trial on the safety and feasibility of low-dose radiotherapy combined with immunochemotherapy for colorectal cancer with liver-limited metastasis (TRIUNITE-04).
Journal of Clinical Oncology2026-01-10
Efficacy and safety of short-course radiotherapy versus total neoadjuvant therapy in older rectal cancer patients: a randomised pragmatic trial (SHAPERS)
ESMO Gastrointestinal Oncology2024-06-012 citations
Quality-of-life outcomes in older patients with early-stage rectal cancer receiving organ-preserving treatment with hypofractionated short-course radiotherapy followed by transanal endoscopic microsurgery (TREC): non-randomised registry of patients unsuitable for total mesorectal excision.
2022-11-1721 citations
STAR-TREC phase II: Can we save the rectum by watchful waiting or transanal surgery following (chemo)radiotherapy versus total mesorectal excision for early rectal cancer?
Journal of Clinical Oncology2022-06-0117 citations
Radiotherapy quality assurance for mesorectum treatment planning within the multi-center phase II STAR-TReC trial: Dutch results.
2020-02-182 citations
Robust dose planning objectives for mesorectal radiotherapy of early stage rectal cancer - A multicentre dose planning study.
2019-09-0114 citations
Radiotherapy in palliation of thoracic tumors: a phase I-II study (SHARON project).
2018-10-087 citations
Can we <i>S</i> ave the rectum by watchful waiting or <i>T</i> rans <i>A</i> nal microsurgery following (chemo) <i>R</i> adiotherapy versus <i>T</i> otal mesorectal excision for early <i>RE</i> ctal <i>C</i> ancer (STAR-TREC study)?: protocol for a multicentre, randomised feasibility study
BMJ Open2017-12-01100 citations