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Sham Intravitreal Injection

OTHER6 trials

Sponsors

GenSight Biologics, Opthea Limited, Imperial College London

Conditions

DiabetesDiabetic Macular EdemaLeber Hereditary Optic NeuropathyNeovascular Age-related Macular DegenerationOptic, Atrophy, Hereditary, Leber

Phase 1

A Dose Ranging Study of OPT-302 With Aflibercept for Persistent Diabetic Macular Edema
CompletedNCT03397264
Opthea LimitedDiabetic Macular Edema
Start: 2018-01-16End: 2020-06-11Updated: 2025-04-22

Phase 2

A Dose Ranging Study of OPT-302 With Ranibizumab in Neovascular (Wet) AMD
CompletedNCT03345082
Opthea LimitedNeovascular Age-related Macular Degeneration
Start: 2017-11-06End: 2019-05-14Updated: 2021-01-12
Combined Ranibizumab and Iluvien for Diabetic Macular Oedema
WithdrawnNCT03784443
Imperial College LondonDiabetes, Diabetic Macular Edema
Start: 2019-09-01End: 2023-09-01Updated: 2023-10-02

Phase 3

Efficacy Study of GS010 for the Treatment of Vision Loss up to 6 Months From Onset in LHON Due to the ND4 Mutation
CompletedNCT02652767
GenSight BiologicsOptic, Atrophy, Hereditary, Leber
Start: 2016-02-23End: 2019-07-04Updated: 2026-03-02
Efficacy Study of GS010 for Treatment of Vision Loss From 7 Months to 1 Year From Onset in LHON Due to the ND4 Mutation (REVERSE)
CompletedNCT02652780
GenSight BiologicsOptic, Atrophy, Hereditary, Leber
Start: 2016-01-01End: 2018-12-01Updated: 2026-03-02
RESCUE and REVERSE Long-term Follow-up
CompletedNCT03406104
GenSight BiologicsLeber Hereditary Optic Neuropathy
Start: 2018-01-09End: 2022-07-04Updated: 2026-03-02

Related Papers

Five-Year Outcomes of Lenadogene Nolparvovec Gene Therapy in Leber Hereditary Optic Neuropathy.
2025-02-017 citations
A Randomized Controlled Trial of OPT-302, a VEGF-C/D Inhibitor for Neovascular Age-Related Macular Degeneration.
2023-02-0633 citations
Indirect Comparison of Lenadogene Nolparvovec Gene Therapy Versus Natural History in Patients with Leber Hereditary Optic Neuropathy Carrying the m.11778G>A MT-ND4 Mutation.
2022-11-3016 citations
Gene Therapies for the Treatment of Leber Hereditary Optic Neuropathy
International Ophthalmology Clinics2021-09-2827 citations
Intravitreal Gene Therapy vs. Natural History in Patients With Leber Hereditary Optic Neuropathy Carrying the m.11778G>A ND4 Mutation: Systematic Review and Indirect Comparison
Frontiers in Neurology2021-05-2456 citations
rAAV2/2-ND4 for the Treatment of LHON: 72-week Data from the REVERSE Phase III Clinical Trial (Plen02.002)
Neurology2019-04-093 citations
267. Phase I Gene Therapy Preliminary Clinical Results for Treatment of ND4 Leber Hereditary Optic Neuropathy with rAAV2-2-ND4
Molecular Therapy2016-05-011 citations