SGM-101

DRUG13 trials

Conditions

Brain CancerBrain DiseasesBrain MetastasesBrain NeoplasmsBrain TumorBrain metastasesColon CancerColorectal Cancer

Phase 1

Phase I of SGM-101 in Patients With Cancer of the Colon, Rectum or Pancreas

CompletedNCT02973672

SurgimabColon Cancer, Metastatic Colorectal Cancer, Pancreas Cancer +2

Start: 2016-01-31End: 2019-05-31Updated: 2019-07-18

Intraoperative Imaging of Pulmonary Nodules by SGM-101

CompletedNCT04315467

Sunil SinghalLung Cancer, Lung Nodule, Non Small Cell Lung Cancer

Start: 2020-07-08End: 2022-02-10Updated: 2022-06-16

Phase 2

SGM-101 in Locally Advanced and Recurrent Rectal Cancer

NCT04642924

Leiden University Medical CenterRectal Cancer, Recurrent Rectal Cancer

Start: 2019-10-22End: 2023-10-31Target: 203Updated: 2020-11-24

SGM-101 in Colorectal Lung Metastases

NCT04737213

Leiden University Medical CenterColorectal Cancer, Metastatic Colon Cancer

Start: 2020-11-01End: 2021-12-01Target: 10Updated: 2021-02-03

SGM-101 in Colorectal Brain Metastases.

RecruitingNCT04755920

Leiden University Medical CenterBrain Cancer, Brain Diseases, Brain Metastases +10

Start: 2024-01-01End: 2026-02-28Target: 10Updated: 2024-05-09

Focus Green: Fluorescence-guided resection Of Colorectal liver metastases Using SGM-101 and Indocyanine GREEN

CompletedCTIS2023-504615-33-00

Leiden University Medical Centercolorectal livermetastases

Start: 2023-12-12End: 2025-05-14Target: 10Updated: 2023-11-09

SGM-101 Tumor Targeted Fluorescence Endoscopy in Rectal Polyps With Suspected T1 Adenocarcinoma or High Grade Dysplasia

RecruitingNCT06280690

Leiden University Medical CenterColorectal Cancer, Image, Low Grade Dysplasia of Colon

Start: 2024-01-31End: 2025-07-30Target: 20Updated: 2024-02-29

SGM-LARRC: Multicenter, open-label, controlled, parallel arms clinical study on the performance of SGM-101, a fluorochrome-labeled anti-carcino-embryonic antigen (CEA) monoclonal antibody, for locally advanced or recurrent rectal cancerpatients undergoing curative surgery.

RecruitingCTIS2024-510768-21-00

Academisch Ziekenhuis LeidenRectal cancer

Start: 2019-10-16Target: 203Updated: 2024-10-01

FLUOPANC II: A performance study of SGM-101, a fluorochrome-labeled anti-carcinoembryonic antigen monoclonal antibody for fluorescence-guided imaging to determine local extent and resectability during surgical resection of pancreatic ductal adenocarcinoma after neoadjuvant treatment.

RecruitingCTIS2023-510481-27-00

Academisch Ziekenhuis LeidenPancreatic tumor

Start: 2023-12-11Target: 60Updated: 2024-10-01

SGM-CBM: A feasibility study of SGM-101, a fluorochrome-labeled anti-carcinoembryonic antigen monoclonal antibody for the intraoperative detection of colorectal brain metastases.

RecruitingCTIS2024-510767-30-00

Academisch Ziekenhuis LeidenBrain metastases

Start: 2023-12-04Target: 10Updated: 2024-10-16

SGM-T1: SGM-101 tumor targeted fluorescence endoscopy in rectal polyps with suspected T1 adenocarcinoma or high grade dysplasia

RecruitingCTIS2024-510769-41-00

Academisch Ziekenhuis LeidenEarly rectal cancer

Start: 2023-12-07Target: 20Updated: 2024-10-16

Phase 3

Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer

RecruitingNCT03659448

SurgimabColorectal Neoplasms

Start: 2019-06-17End: 2024-12-31Target: 300Updated: 2024-04-24

Unknown Phase

Study in Patients With Peritoneal Carcinomatosis From CEA Overexpressing Digestive Cancer

CompletedNCT02784028

Institut du Cancer de Montpellier - Val d'AurellePeritoneal Carcinomatosis

Start: 2014-12-31End: 2017-12-08Updated: 2020-10-20

European Journal of Nuclear Medicine and Molecular Imaging2026-09-03

Intraoperative molecular imaging of colorectal lung metastases with SGM-101: a feasibility study

European Journal of Nuclear Medicine and Molecular Imaging2023-08-086 citations

Carcinoembryonic Antigen–Related Cell Adhesion Molecule Type 5 Receptor–Targeted Fluorescent Intraoperative Molecular Imaging Tracer for Lung Cancer

JAMA Network Open2023-01-2715 citations

Safety and effectiveness of SGM-101, a fluorescent antibody targeting carcinoembryonic antigen, for intraoperative detection of colorectal cancer: a dose-escalation pilot study.

2018-01-30134 citations