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Semaglutide (Rybelsus®)

DRUG9 trials

Sponsors

Vanderbilt University Medical Center, University of Yaounde 1, Rune Skovgaard Rasmussen, First Affiliated Hospital of Wenzhou Medical University, Imperial College London

Conditions

Acute Myocardial Infarction With ST ElevationAlcoholAlzheimer DiseaseAlzheimer Disease (AD)Appetite RegulationCardiovascular Disease PreventionDiabetes Mellitus - Type 2Epicardial Fat

Early Phase 1

GLP-1Ra Impact on Metabolic Outcomes in Stage 2 T1DM While Receiving Teplizumab
RecruitingNCT06338553
Vanderbilt University Medical CenterType 1 Diabetes
Start: 2024-06-12End: 2027-03-31Target: 24Updated: 2025-12-18

Phase 1

Effect of Aqueous Extracts of Cissus Quadrangularis and Dichrostachys Glomerata on GLP-1 Concentration and DPP-4 Activity in Overweight and Obese Adults
Active, not recruitingNCT06827002
University of Yaounde 1Appetite Regulation, Obesity and Overweight
Start: 2023-02-12End: 2026-01-31Updated: 2025-10-14

Phase 2

Improved Treatment and Monitoring of Alzheimer's Disease
Not yet recruitingNCT07135245
Rune Skovgaard RasmussenAlzheimer Disease (AD)
Start: 2026-01-01End: 2031-09-30Target: 180Updated: 2025-08-22
Can Fat-Burning Shots Boost Fertility? Comparing Weight-Loss Injections vs. Healthy Habits for Obese Men With Low Sperm Health
Not yet recruitingNCT07179120
First Affiliated Hospital of Wenzhou Medical UniversityObesity-related Male Infertility
Start: 2026-05-01End: 2027-01-02Target: 180Updated: 2025-09-17
Oral Semaglutide in Patients With Alzheimer's Disease
Not yet recruitingNCT07200622
Imperial College LondonAlzheimer Disease
Start: 2025-09-25End: 2028-12-31Target: 60Updated: 2025-10-01
GLP-1 Receptor Agonists to Decrease Ethanol and CVD Risk in HIV
Not yet recruitingNCT07221214
Vanderbilt University Medical CenterAlcohol, Cardiovascular Disease Prevention, HIV +1
Start: 2026-03-31End: 2030-07-31Target: 200Updated: 2026-03-16

Phase 3

Effect of Glp-1 and Antidiabetic sgLT2 Agents for myoCardial infarcTion and Ultrasensitive Inflammatory Surveillance (GALACTUS Trial)
RecruitingNCT07295223
Instituto Mexicano del Seguro SocialAcute Myocardial Infarction With ST Elevation
Start: 2025-12-30End: 2026-09-30Target: 44Updated: 2026-01-05
Epicardial Cardiac Fat-CT (EPIC-CT)
RecruitingNCT07297589
Instituto Mexicano del Seguro SocialEpicardial Fat, STEMI - ST Elevation Myocardial Infarction
Start: 2025-12-30End: 2027-03-31Target: 136Updated: 2026-01-02

Phase 4

Effects of Semaglutide on Clinical Outcomes and Metabolic Inflammation in Psoriasis
RecruitingNCT07401992
Hospital Universitario Dr. Jose E. GonzalezDiabetes Mellitus - Type 2, Obesity & Overweight, Psoriasis (PsO)
Start: 2026-01-15End: 2027-02-28Target: 62Updated: 2026-02-11