Seltorexant

DRUG11 trials

Sponsors

Janssen Research & Development, LLC

Conditions

Abuse PotentialAlzheimer DiseaseDepressive Disorder, MajorHealthyHealthy Non-dependent, Recreational Sedative Users

Phase 1

A Study to Evaluate the Effects of Single-dose Seltorexant on Electrocardiogram Intervals in Healthy Adult Participants

CompletedNCT03494907

Janssen Research & Development, LLCHealthy

Start: 2018-04-09End: 2018-08-13Updated: 2025-04-27

A Study of Seltorexant in Healthy Participants

CompletedNCT04553042

Janssen Research & Development, LLCHealthy

Start: 2020-09-14End: 2020-12-30Updated: 2025-04-27

A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adolescents With Major Depressive Disorder Who Have an Inadequate Response to Selective Serotonin Reuptake Inhibitor (SSRI) and Psychotherapy

TerminatedNCT04951609

Janssen Research & Development, LLCDepressive Disorder, Major

Start: 2021-09-02End: 2024-04-08Updated: 2025-04-27

A Study to Determine the Abuse Potential of Seltorexant Compared to Suvorexant and Zolpidem

CompletedNCT05106153

Janssen Research & Development, LLCAbuse Potential, Healthy Non-dependent, Recreational Sedative Users

Start: 2021-12-17End: 2023-05-12Updated: 2025-04-27

A Study of JNJ-42847922 (Seltorexant) in Healthy Participants

CompletedNCT05236868

Janssen Research & Development, LLCHealthy

Start: 2022-02-03End: 2022-03-01Updated: 2025-04-27

Phase 2

A Study of Seltorexant in Participants With Probable Alzheimer's Disease

CompletedNCT05307692

Janssen Research & Development, LLCAlzheimer Disease

Start: 2022-05-19End: 2023-11-10Updated: 2025-04-27

Phase 3

A Study of Seltorexant Compared to Quetiapine XR as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy

CompletedNCT04513912

Janssen Research & Development, LLCDepressive Disorder, Major

Start: 2020-09-15End: 2023-10-03Updated: 2025-08-13

A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant and Long-term Safety Extension Treatment With Seltorexant

CompletedNCT04533529

Janssen Research & Development, LLCDepressive Disorder, Major

Start: 2020-09-16End: 2024-04-30Updated: 2026-05-12

A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy

TerminatedNCT04532749

Janssen Research & Development, LLCDepressive Disorder, Major

Start: 2020-09-15End: 2022-07-14Updated: 2025-06-04

Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

RecruitingNCT06559306

Janssen Research & Development, LLCDepressive Disorder, Major

Start: 2024-07-25End: 2027-04-15Target: 752Updated: 2026-08-28

A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

RecruitingNCT07573176

Janssen Research & Development, LLCDepressive Disorder, Major

Start: 2026-04-30End: 2029-05-03Target: 600Updated: 2026-08-28

Related Papers

Efficacy and Safety of Seltorexant as Adjunctive Therapy in Major Depressive Disorder: A Phase 2b, Randomized, Placebo-Controlled, Adaptive Dose-Finding Study

The International Journal of Neuropsychopharmacology2021-07-2855 citations