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SEL120 monohydrochloride

DRUG6 trials

Sponsors

Ryvu Therapeutics S.A., GCP-Service International West GmbH

Conditions

Acute Myeloid LeukemiaAcute Myeloid Leukemia with or without NPM1 MutationAnemia in patients with very lowMyelofibrosisRelapsed / Refractory Metastatic or Advanced Solid TumorsRelapsed or Refractory High-Risk Myelodysplastic Syndromelow or intermediate risk myelodysplastic neoplasms (MDS)

Phase 2

A Multicenter, Open-Label, Dose-Finding Clinical Trial to Assess the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Efficacy of RVU120 in Combination with Venetoclax in Participants with Acute Myeloid Leukemia Who Failed Prior Therapy with Venetoclax and a Hypomethylating Agent (RIVER-81)
RecruitingCTIS2023-505911-19-00
Ryvu Therapeutics S.A.Acute Myeloid Leukemia
Start: 2024-01-05Target: 129Updated: 2025-12-10
A Multicenter, Open-Label Clinical Trial of RVU120 in Patients with Relapsed or Refractory High-Risk Myelodysplastic Syndrome or Acute Myeloid Leukemia with or without NPM1 Mutation (RIVER-52)
CompletedCTIS2023-505910-10-00
Ryvu Therapeutics S.A.Acute Myeloid Leukemia with or without NPM1 Mutation, Relapsed or Refractory High-Risk Myelodysplastic Syndrome
Start: 2024-01-23End: 2025-08-27Target: 174Updated: 2025-08-19
A phase II, open-label, multicenter study of orally administered RVU120 for the treatment of anemia in patients with lower-risk myelodysplastic neoplasms (MDS)
Active, not recruitingCTIS2023-509947-29-00
GCP-Service International West GmbHAnemia in patients with very low, low or intermediate risk myelodysplastic neoplasms (MDS)
Start: 2024-07-18Target: 45Updated: 2025-11-13
An Open-label, Single Agent, Phase I/II Trial Investigating the Safety and Efficacy of RVU120 (SEL120) in Patients with Relapsed / Refractory Metastatic or Advanced Solid Tumors
CompletedCTIS2024-515131-30-00
Ryvu Therapeutics S.A.Relapsed / Refractory Metastatic or Advanced Solid Tumors
Start: 2023-12-18End: 2025-10-02Target: 54Updated: 2024-08-12
An Open-Label Clinical Trial of RVU120 as Monotherapy and in Combination with Ruxolitinib in Patients with Intermediate or High-Risk, Primary or Secondary Myelofibrosis (POTAMI-61)
RecruitingCTIS2024-511688-27-00
Ryvu Therapeutics S.A.Myelofibrosis
Start: 2024-09-19Target: 83Updated: 2025-12-16
An Open-label Multicenter Rollover Study to Provide Continued Treatment to Participants Previously Enrolled in a RVU120 Clinical Study
Not yet recruitingCTIS2025-521673-14-00
Ryvu Therapeutics S.A.Acute Myeloid Leukemia with or without NPM1 Mutation, Relapsed or Refractory High-Risk Myelodysplastic Syndrome, Relapsed / Refractory Metastatic or Advanced Solid Tumors
Target: 20Updated: 2026-01-26