SEL120 monohydrochloride
Sponsors
Ryvu Therapeutics S.A., GCP-Service International West GmbH
Conditions
Acute Myeloid LeukemiaAcute Myeloid Leukemia with or without NPM1 MutationAnemia in patients with very lowMyelofibrosisRelapsed / Refractory Metastatic or Advanced Solid TumorsRelapsed or Refractory High-Risk Myelodysplastic Syndromelow or intermediate risk myelodysplastic neoplasms (MDS)
Phase 2
A Multicenter, Open-Label, Dose-Finding Clinical Trial to Assess the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Efficacy of RVU120 in Combination with Venetoclax in Participants with Acute Myeloid Leukemia Who Failed Prior Therapy with Venetoclax and a Hypomethylating Agent (RIVER-81)
RecruitingCTIS2023-505911-19-00
Start: 2024-01-05Target: 129Updated: 2025-12-10
A Multicenter, Open-Label Clinical Trial of RVU120 in Patients with Relapsed or Refractory High-Risk Myelodysplastic Syndrome or Acute Myeloid Leukemia with or without NPM1 Mutation (RIVER-52)
CompletedCTIS2023-505910-10-00
Start: 2024-01-23End: 2025-08-27Target: 174Updated: 2025-08-19
A phase II, open-label, multicenter study of orally administered RVU120 for the treatment of anemia in patients with lower-risk myelodysplastic neoplasms (MDS)
Active, not recruitingCTIS2023-509947-29-00
Start: 2024-07-18Target: 45Updated: 2025-11-13
An Open-label, Single Agent, Phase I/II Trial Investigating the Safety and Efficacy of RVU120 (SEL120) in Patients with Relapsed / Refractory Metastatic or Advanced Solid Tumors
CompletedCTIS2024-515131-30-00
Start: 2023-12-18End: 2025-10-02Target: 54Updated: 2024-08-12
An Open-Label Clinical Trial of RVU120 as Monotherapy and in Combination with Ruxolitinib in Patients with Intermediate or High-Risk, Primary or Secondary Myelofibrosis (POTAMI-61)
RecruitingCTIS2024-511688-27-00
Start: 2024-09-19Target: 83Updated: 2025-12-16
An Open-label Multicenter Rollover Study to Provide Continued Treatment to Participants Previously Enrolled in a RVU120 Clinical Study
Not yet recruitingCTIS2025-521673-14-00
Target: 20Updated: 2026-01-26