SC-CAR.GPC3xIL15.21 CAR T cells

BIOLOGICAL2 trials

Sponsors

Seattle Children's Hospital

Conditions

Embryonal Sarcoma of LiverHepatoblastomaHepatocellular CarcinomaLiposarcomaLiver Cell CarcinomaMalignant Rhabdoid TumorRhabdomyosarcomaSolid Tumor (Excluding CNS)

Phase 1

Immunotherapy for Solid Tumor Malignancies in Pediatrics Using Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor T Cells

RecruitingNCT07148050

Seattle Children's HospitalEmbryonal Sarcoma of Liver, Hepatoblastoma, Hepatocellular Carcinoma +7

Start: 2025-12-22End: 2044-04-22Target: 21Updated: 2026-02-17

Cytokine Armored GPC3 Specific Chimeric Antigen Receptor Expressing T-cells in Adults With Solid Tumors

Not yet recruitingNCT07224568

Seattle Children's HospitalHepatocellular Carcinoma, Liposarcoma, Liver Cell Carcinoma +3

Start: 2026-04-01End: 2045-08-31Target: 21Updated: 2025-11-04