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Sapropterin

DRUG9 trials

Sponsors

The Children's Health Council, University of California, San Diego, University of Missouri-Columbia, Children's Hospital of Philadelphia, University of Utah

Conditions

Autistic DisorderBehavioral Manifestations of Lesch-Nyhan DiseaseGTP Cyclohydrolase DeficiencyHyperphenylalaninemiaLiver CirrhosisPhenylketonuriaPhenylketonuriasPortal Hypertension

Phase 1

Study of Kuvan Treatment in Adults With GTPCH Deficiency
CompletedNCT01425528
University of UtahGTP Cyclohydrolase Deficiency
Start: 2011-08-31End: 2013-08-31Updated: 2025-04-01

Phase 2

Sapropterin as a Treatment for Autistic Disorder
CompletedNCT00850070
The Children's Health CouncilAutistic Disorder
Start: 2009-03-31End: 2011-10-31Updated: 2018-05-01
Trial of Kuvan in Lesch-Nyhan Disease
WithdrawnNCT00935753
University of California, San DiegoBehavioral Manifestations of Lesch-Nyhan Disease
Start: 2009-04-30End: 2010-02-28Updated: 2019-08-02
Randomized Controlled Trial to Assess the Effects of Sapropterin on Hepatic and Systemic Hemodynamics in Patients With Liver Cirrhosis and Portal Hypertension
CompletedNCT01456286
Fundacion Clinic per a la Recerca BiomédicaLiver Cirrhosis, Portal Hypertension
Start: 2011-10-31End: 2013-10-31Updated: 2013-10-07
Sapropterin on Cognitive Abilities in Young Adults With Phenylketonuria
TerminatedNCT01977820
BioMarin PharmaceuticalPhenylketonuria
Start: 2014-02-28End: 2014-11-30Updated: 2018-02-22

Unknown Phase

The Effects of Kuvan on Functional Brain Connectivity in Individuals With Phenylketonuria (PKU)
CompletedNCT00964236
University of Missouri-ColumbiaPhenylketonuria
Start: 2009-08-31End: 2011-08-31Updated: 2018-01-04
Fluorodeoxyglucose Positron Emission Tomography (FDG PET) Findings in Patients With Phenylketonuria Before and After KUVAN Therapy
CompletedNCT00986973
Children's Hospital of PhiladelphiaPhenylketonuria
Start: 2010-03-31End: 2011-09-30Updated: 2015-06-08
Bone Mineral Density in Adults With Hyperphenylalaninemia on Kuvan Therapy
TerminatedNCT01541397
The University of Texas Health Science Center, HoustonHyperphenylalaninemia, Phenylketonuria
Start: 2011-06-30End: 2012-08-31Updated: 2015-07-07
Nutritional Status in Phenylketonuria
CompletedNCT03820804
Universidade do PortoPhenylketonurias
Start: 2019-01-07End: 2019-09-10Updated: 2019-09-10

Related Papers

Tetrahydrobiopterin as a Treatment for Autism Spectrum Disorders: A Double-Blind, Placebo-Controlled Trial
Journal of Child and Adolescent Psychopharmacology2013-06-0160 citations