Saline -- placebo comparator

DRUG3 trials

Sponsors

University of Colorado, Denver, Cairo University, Istanbul University

Conditions

Alzheimer's DiseaseHyaluronic AcidKnee OsteoarthritisPatients with Jaw Muscles Myofascial Pain

Phase 2

Study of the Safety & Efficacy of Leukine® in the Treatment of Alzheimer's Disease

CompletedNCT01409915

University of Colorado, DenverAlzheimer's Disease

Start: 2011-03-31End: 2019-12-09Updated: 2021-06-02

A Comparative Study on the Impact of Trigger Points Injection of Platelet Rich Plasma Versus Botulinum Toxin on the Relief of Jaw Muscles Myofascial Pain

Active, not recruitingNCT06814535

Cairo UniversityPatients with Jaw Muscles Myofascial Pain

Start: 2024-06-01End: 2025-03-31Updated: 2025-03-11

Unknown Phase

The Effect of Hyaluronic Acid Injection on TNF-Alpha and IL-1β in Knee Osteoarthritis

RecruitingNCT06960564

Istanbul UniversityHyaluronic Acid, Knee Osteoarthritis

Start: 2025-05-12End: 2026-03-29Target: 50Updated: 2026-01-09

Related Papers

GM‐CSF reduces amylin amyloid, inhibits pancreatic apoptosis, and sustains lowered blood glucose levels in the hIAPP mouse model of Type 2 diabetes mellitus, a known risk factor for Alzheimer’s disease

Alzheimer s & Dementia2023-12-01

The Potential Alzheimer’s Disease Drug, GM‐CSF, Enhances the Anti‐Viral Immune Response and Reduces Mortality in a Mouse Model of COVID‐19

Alzheimer s & Dementia2022-12-01

GM‐CSF reduces amylin amyloid and prevents pancreatic cell death in the hIAPP mouse model of Type 2 diabetes mellitus, a known risk factor for Alzheimer’s disease

Alzheimer s & Dementia2022-12-01

Safety and efficacy of sargramostim (GM‐CSF) in the treatment of Alzheimer's disease

Alzheimer s & Dementia Translational Research & Clinical Interventions2021-01-0187 citations

Double‐blind placebo‐controlled trial of the safety and efficacy of GM‐CSF/sargramostim in subjects with mild‐to‐moderate Alzheimer’s disease

Alzheimer s & Dementia2020-12-01

A multiancestry analysis of Alzheimer’s disease coexpressed gene networks identifies a common immune signaling pathway regulated by granulocyte‐colony stimulating factor (G‐CSF)

Alzheimer s & Dementia2020-12-01