Safinamide
Sponsors
Fundacio Institut De Recerca De L Hospital De La Santa Creu I Sant Pau, Newron Pharmaceuticals SPA, IRCCS San Raffaele Roma, Zambon SpA, Alain Kaelin
Conditions
Fatigue symptoms associated with Parkinson´s Disease.Hepatic ImpairmentIdiopathic Parkinson's DiseaseIdiopathic Parkinson's Disease (at Later Stage)PARKINSON DISEASE (Disorder)PainPain ManagementParkinson Disease
Phase 1
Phase 2
Safinamide in Levodopa Induced Dyskinesia in Parkinson's Disease Subjects
CompletedNCT01113320
Start: 2010-04-30End: 2012-01-31Updated: 2013-03-29
A Trial to Explore the Potential Benefit of Safinamide on Cognitive Impairment Associated With Parkinson's Disease
CompletedNCT01211587
Start: 2010-09-30Updated: 2013-03-29
A Study to Evaluate Safinamide's Effect on Dopamine and Serotonin's Availability by Using Brain Imaging
TerminatedNCT01264861
Start: 2011-03-31End: 2012-01-24Updated: 2017-09-18
Phase 3
Safinamide as Add-On Therapy in Patients With Early Idiopathic Parkinson's Disease Treated With a Stable Dose of a Single Dopamine Agonist
CompletedNCT00643045
Start: 2004-12-31End: 2007-07-31Updated: 2008-03-25
Safinamide as Add-On Therapy in Patients With Early Idiopathic Parkinson's Disease Treated With a Stable Dose of a Single Dopamine Agonist (12 Month Extension)
CompletedNCT00642889
Start: 2005-06-30End: 2007-07-31Updated: 2008-03-25
Open-Label Trial to Determine the Long-Term Safety of Safinamide in Parkinson's Disease Patients
TerminatedNCT00865579
Start: 2009-04-30End: 2012-06-30Updated: 2017-09-18
Efficacy and Safety of Safinamide (50 and 100mg/Day) Versus Placebo, in Patients With Mid-late Stage Parkinson's Disease
CompletedNCT01187966
Start: 2007-01-31End: 2009-02-28Updated: 2010-08-24
18-month Study of Long-term Efficacy & Safety of Safinamide as add-on Therapy in Patients With Mid-late Stage PD
CompletedNCT01286935
Start: 2007-08-31End: 2010-08-31Updated: 2011-01-31
A Study to Evaluate the Efficacy and Safety of Safinamide, as add-on Therapy, in Idiopathic Chinese Parkinson's Disease (PD) Patients With Motor Fluctuations Treated With Stable Doses of Levodopa
CompletedNCT03881371
Start: 2019-08-01End: 2021-08-20Updated: 2024-03-20
Safinamide vs Placebo for Pain in Patients With Parkinson's Disease and Motor Fluctuations
RecruitingNCT07761936
Start: 2026-04-28End: 2027-12-01Target: 60Updated: 2026-08-13
Phase 4
Overnight Switch From Rasagiline To Safinamide
CompletedNCT03843944
Start: 2018-05-01End: 2019-05-31Updated: 2024-04-10
Effect of Safinamide on Sleep Quality in Patients With Parkinson's Disease
TerminatedNCT03968744
Start: 2019-02-18End: 2026-02-02Updated: 2026-03-13
Independent, multicenter, phase IV, randomized, double-blind, parallel-group clinical trial in people with Parkinson's Disease under stable dopaminergic treatment with persistent fatigue symptoms, randomized 1:1 to adjunctive treatment with safinamide (100 mg/day) or rasagiline (1 mg/day) for 24 weeks.
RecruitingCTIS2023-503713-29-00
Start: 2023-12-13Target: 50Updated: 2025-07-23