sacubitril/valsartan (LCZ696)

DRUG3 trials

Sponsors

Novartis Pharmaceuticals

Conditions

Acute Heart FailureHeart Failure, Reduced Ejection FractionHypertension

Phase 2

A Study to Evaluate the Effect of LCZ696 on Aortic Stiffness in Subjects With Hypertension

CompletedNCT01870739

Novartis PharmaceuticalsHypertension

Start: 2013-10-31End: 2015-06-30Updated: 2021-01-05

Phase 4

Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode.

CompletedNCT02554890

Novartis PharmaceuticalsAcute Heart Failure

Start: 2016-04-29End: 2018-07-24Updated: 2021-01-05

Study on the Effects of Sacubitril/Valsartan on Physical Activity and Sleep in Heart Failure With Reduced Ejection Fraction Patients.

CompletedNCT02970669

Novartis PharmaceuticalsHeart Failure, Reduced Ejection Fraction

Start: 2016-12-16End: 2018-03-19Updated: 2021-10-07

Related Papers

Sacubitril/Valsartan in Patients Hospitalized With Decompensated Heart Failure

Journal of the American College of Cardiology2024-03-0121 citations

The AWAKE-HF Study: Sacubitril/Valsartan Impact on Daily Physical Activity and Sleep in Heart Failure.

2020-09-2622 citations

Angiotensin-Neprilysin Inhibition in Black Americans

JACC Heart Failure2020-09-0918 citations

Angiotensin Receptor-Neprilysin Inhibition Based on History of Heart Failure and Use of Renin-Angiotensin System Antagonists.

2020-09-0141 citations

Efficacy and Safety of Sacubitril/Valsartan by Dose Level Achieved in the PIONEER-HF Trial

JACC Heart Failure2020-08-1236 citations

Variability of MRI Aortic Stiffness Measurements in a Multicenter Clinical Trial Setting: Intraobserver, Interobserver, and Intracenter Variability of Pulse Wave Velocity and Aortic Strain Measurement.

2020-04-307 citations

Understanding the early mortality benefit observed in the PARADIGM-HF trial: considerations for the management of heart failure with sacubitril/valsartan.

2020-01-1613 citations

On the optimal temporal resolution for phase contrast cardiovascular magnetic resonance imaging: establishment of baseline values

Journal of Cardiovascular Magnetic Resonance2020-01-0112 citations

Initiation of Angiotensin-Neprilysin Inhibition After Acute Decompensated Heart Failure

JAMA Cardiology2019-12-1186 citations

Cardiovascular biomarkers in patients with acute decompensated heart failure randomized to sacubitril-valsartan or enalapril in the PIONEER-HF trial.

2019-10-0149 citations

Angiotensin–Neprilysin Inhibition in Acute Decompensated Heart Failure

New England Journal of Medicine2018-11-111207 citations