Sacubitril / Valsartan

DRUG5 trials

Sponsors

John Paul II Hospital, Krakow, Puerta de Hierro University Hospital, National Heart Institute, Egypt, University Clinical Hospital Mostar, Khawaja Danish Ali

Conditions

Acute Decompensated Heart Failure (ADHF)Chronic Kidney Disease (CKD)Decompensated Heart FailureHeart Failure With Preserved Ejection Fraction (HFPEF)Heart Failure with Moderately Reduced Ejection FractionHemodialysisSacubitril/ValsartanTransthyretin Amyloidosis Cardiomyopathy (ATTR-CM)

Phase 1

Vericiguat in Decompensated Cardiac Failure: Clinical Insights on Addition to Guidelines Derived Medical Therapy-VERCIG Trial

RecruitingNCT07444398

Khawaja Danish AliDecompensated Heart Failure

Start: 2026-01-01End: 2026-03-31Target: 130Updated: 2026-03-02

Phase 2

Comparative Assessment of Efficacy & Safety of Sacubitril/Valsartan Versus Ramipril in Patients With Renal Dysfunction Hospitalized With Acute Decompensated Heart Failure

CompletedNCT07023016

National Heart Institute, EgyptAcute Decompensated Heart Failure (ADHF), Chronic Kidney Disease (CKD)

Start: 2023-11-01End: 2025-02-28Updated: 2025-06-22

Phase 3

The Effect of Sacubitril/valsartan Versus Ramipril on Left Ventricular Function and Remodeling in Patients with Ischemic Heart Failure with Mid-range Ejection Fraction

RecruitingNCT05508035

John Paul II Hospital, KrakowHeart Failure with Moderately Reduced Ejection Fraction

Start: 2023-07-13End: 2027-06-30Target: 666Updated: 2024-10-31

Effect of Angiotensin Receptor/Neprilysin Inhibitors on Transthyretin Cardiac Amyloidosis and Heart Failure with Reduced Ejection Fraction

Not yet recruitingNCT06712030

Puerta de Hierro University HospitalTransthyretin Amyloidosis Cardiomyopathy (ATTR-CM)

Start: 2025-01-31End: 2027-06-30Target: 114Updated: 2024-12-02

Phase 4

The Effect of Sacubitril and Valsartan on Heart Function in Chronic Hemodialysis Patients With HFpEF

Not yet recruitingNCT07417215

University Clinical Hospital MostarHeart Failure With Preserved Ejection Fraction (HFPEF), Hemodialysis, Sacubitril/Valsartan

Start: 2026-01-30End: 2026-04-10Target: 60Updated: 2026-02-18