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Sacituzumab Tirumotecan (SKB264)

DRUG4 trials

Sponsors

Zhejiang Provincial People's Hospital, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Alianza multidisciplinar para la investigación de los tumores genitourinarios -GUARD, Shaodong Hong

Conditions

Advanced Biliary Tract Cancer(BTC)Advanced Thyroid CarcinomaNon-Small Cell Lung CancerPapillary Renal CarcinomaPoorly Differentiated Thyroid CarcinomaRadioiodine-refractory Differentiated Thyroid CancerVariant Histology Urothelial Carcinoma

Phase 2

Sacituzumab Tirumotecan in Previously Treated TROP2-Positive Advanced Biliary Tract Cancer
Not yet recruitingNCT07701122
Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAdvanced Biliary Tract Cancer(BTC)
Start: 2026-07-01End: 2028-07-01Target: 33Updated: 2026-07-14
Genitourinary Tumors With Sacituzumab Tirumotecan
Not yet recruitingNCT07716917
Alianza multidisciplinar para la investigación de los tumores genitourinarios -GUARDPapillary Renal Carcinoma, Variant Histology Urothelial Carcinoma
Start: 2026-10-01End: 2029-12-01Target: 100Updated: 2026-07-23
Toripalimab Plus Sacituzumab Tirumotecan as Neoadjuvant Therapy for Resectable NSCLC
Not yet recruitingNCT07819578
Shaodong HongNon-Small Cell Lung Cancer
Start: 2026-10-01End: 2028-12-01Target: 30Updated: 2026-09-15

Unknown Phase

Sacituzumab Tirumotecan Combined With Immunotherapy in Advanced Thyroid Cancer
RecruitingNCT07068542
Zhejiang Provincial People's HospitalAdvanced Thyroid Carcinoma, Poorly Differentiated Thyroid Carcinoma, Radioiodine-refractory Differentiated Thyroid Cancer
Start: 2025-07-01End: 2028-12-31Target: 94Updated: 2026-06-01