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Ruxolitinib 1.5% cream

DRUG6 trials

Sponsors

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Milton S. Hershey Medical Center, Incyte Corporation, Icahn School of Medicine at Mount Sinai, Innovaderm Research Inc.

Conditions

Acute Skin Graft Versus Host Disease (GVHD)Discoid Lupus ErythematosusGraft Versus Host DiseaseHidradenitis SuppurativaJNS KinaseSeborrheic DermatitisTopical AdministrationVitiligo

Phase 1

Topical Ruxolitinib in Acute Skin GVHD (Graft Versus Host Disease)
Not yet recruitingNCT07801248
Children's Hospital Medical Center, CincinnatiAcute Skin Graft Versus Host Disease (GVHD)
Start: 2026-10-01End: 2029-10-01Target: 10Updated: 2026-09-08

Phase 2

Topical Ruxolitinib for Cutaneous Chronic Graft Versus Host Disease (cGVHD)
TerminatedNCT03395340
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Graft Versus Host Disease, JNS Kinase, Topical Administration
Start: 2018-11-19End: 2019-01-31Updated: 2022-07-12
Topical Ruxolitinib 1.5% for Hidradenitis Suppurativa Treatment
TerminatedNCT04414514
Milton S. Hershey Medical CenterHidradenitis Suppurativa
Start: 2022-10-13End: 2024-02-23Updated: 2026-04-28
A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream With Phototherapy in Participants With Vitiligo
CompletedNCT05247489
Incyte CorporationVitiligo
Start: 2022-05-05End: 2023-12-19Updated: 2025-02-20
Ruxolitinib in Seborrheic Dermatitis
CompletedNCT05787860
Icahn School of Medicine at Mount SinaiSeborrheic Dermatitis
Start: 2022-11-15End: 2024-01-26Updated: 2025-05-06
Study to Evaluate the Efficacy of Ruxolitinib 1.5% Cream in Adult Subjects with Discoid Lupus Erythematosus
RecruitingNCT06261021
Innovaderm Research Inc.Discoid Lupus Erythematosus
Start: 2024-04-19End: 2026-02-28Target: 20Updated: 2025-03-24

Related Papers

Pilot study of topical ruxolitinib demonstrates efficacy and blunting of heterogeneous inflammatory processes in mild hidradenitis suppurativa
British Journal of Dermatology2024-12-217 citations