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RTS,S/AS01

BIOLOGICAL2 trials

Sponsors

London School of Hygiene and Tropical Medicine

Conditions

Child, OnlyChildren, OnlyMalaria,Falciparum

Phase 3

Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ)
CompletedNCT03143218
London School of Hygiene and Tropical MedicineChildren, Only, Malaria,Falciparum
Start: 2017-04-17End: 2020-03-31Updated: 2022-04-07
Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ) Extension Study
CompletedNCT04319380
London School of Hygiene and Tropical MedicineChild, Only, Malaria,Falciparum
Start: 2020-04-01End: 2022-03-31Updated: 2024-09-20

Related Papers

Clinical presentation of severe malaria in children who received the RTS,S/AS01E malaria vaccine, seasonal malaria chemoprevention or the combination of both interventions in Burkina Faso and Mali
Malaria Journal2026-07-22
Clinical presentation of severe malaria in children who received the RTS,S/AS01E malaria vaccine, seasonal malaria chemoprevention or the combination of both interventions in Burkina Faso and Mali.
2026-02-14
The anti-circumsporozoite antibody response to repeated, seasonal booster doses of the malaria vaccine RTS,S/AS01<sub>E</sub>.
2025-02-061 citations
Exploring the host factors affecting asymptomatic Plasmodium falciparum infection: insights from a rural Burkina Faso study.
2023-09-01
Seasonal vaccination with RTS,S/AS01<sub>E</sub> vaccine with or without seasonal malaria chemoprevention in children up to the age of 5 years in Burkina Faso and Mali: a double-blind, randomised, controlled, phase 3 trial.
2023-08-2242 citations
The duration of protection against clinical malaria provided by the combination of seasonal RTS,S/AS01E vaccination and seasonal malaria chemoprevention versus either intervention given alone
BMC Medicine2022-10-0729 citations
Impact of seasonal RTS,S/AS01E vaccination plus seasonal malaria chemoprevention on the nutritional status of children in Burkina Faso and Mali
Malaria Journal2022-02-222 citations
The Anti-Circumsporozoite Antibody Response of Children to Seasonal Vaccination With the RTS,S/AS01E Malaria Vaccine
Clinical Infectious Diseases2021-12-109 citations
Seasonal Malaria Vaccination with or without Seasonal Malaria Chemoprevention
New England Journal of Medicine2021-08-25215 citations
Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial.
2021-05-05326 citations
Seasonal malaria vaccination: protocol of a phase 3 trial of seasonal vaccination with the RTS,S/AS01<sub>E</sub>vaccine, seasonal malaria chemoprevention and the combination of vaccination and chemoprevention
BMJ Open2020-09-0116 citations
Evaluation of seasonal malaria chemoprevention in two areas of intense seasonal malaria transmission: Secondary analysis of a household-randomised, placebo-controlled trial in Houndé District, Burkina Faso and Bougouni District, Mali
PLoS Medicine2020-08-2151 citations
A Phase IIa Controlled Human Malaria Infection and Immunogenicity Study of RTS,S/AS01E and RTS,S/AS01B Delayed Fractional Dose Regimens in Malaria-Naive Adults
The Journal of Infectious Diseases2020-07-1744 citations