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DRUG12 trials

Sponsors

Pharmacosmos A/S, Medical University Of Lodz, Narodowy Instytut Onkologii Im. Marii Sklodowskiej-Curie-Panstwowy Instytut Badawczy, Uniwersytet Jagiellonski Collegium Medicum, Medical University Of Gdansk

Conditions

Acute Myeloid LeucaemiaAcute Myeloid LeukemiaAcute ischemic strokeAcute myeloid leukemiaDiffuse large B-cell lymphoma) and aggressive B-cell lymphomas (HGBCLDiffuse large B-cell lymphomas (DLBCLExtensive Stage Small Cell Lung CancerHER2 negative breast cancer

Phase 1

Phase 2

A phase II study of preoperative stereotactic radiation therapy boost combined with short-course immunotherapy (pembrolizumab versus placebo, randomized, double-blind) and standard chemotherapy in patients with newly diagnosed HER2-negative non-metastatic breast cancer with lack of early metabolic response in 18-fluorodeoxyglucoseFDG-PET/CT after 1st chemoterapy cycle
RecruitingCTIS2023-504145-31-00
Narodowy Instytut Onkologii Im. Marii Sklodowskiej-Curie-Panstwowy Instytut BadawczyHER2 negative breast cancer
Start: 2024-06-10Target: 78Updated: 2024-02-21
Assessment of Tolerance and Effectiveness of Total Body Irradiation and Cladribine Before Allogeneic Hematopoietic Cell Transplantation in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndromes
Active, not recruitingCTIS2024-517477-24-00
Narodowy Instytut Onkologii Im. Marii Sklodowskiej-Curie Panstwowy Instytut BadawczyAcute myeloid leukemia, myelodysplastic syndromes
Start: 2022-02-17Target: 40Updated: 2025-04-02
A phase II efficacy and safety study of cell-free circulating tumor DNA-guided commencement of second-line treatment in patients with DLBCL/HGBCL relapse
Not yet recruitingCTIS2024-518275-64-00
Instytut Hematologii I TransfuzjologiiDiffuse large B-cell lymphoma) and aggressive B-cell lymphomas (HGBCL, Diffuse large B-cell lymphomas (DLBCL, High-grade B-cell lymphoma) originate from mature B-cells at various stages of terminal differentiation
Target: 340Updated: 2025-11-24
A multicentre, parallel group, randomised, double blind, placebo-controlled, phase II study evaluating the efficacy and safety of reperfusion thrombolytic therapy with intravenous recombinant tissue plasminogen activator (rtPA) for ischaemic stroke in patients on the non-vitamin K antagonist oral anticoagulant after reversing anticoagulant activity with the specific antidote
RecruitingCTIS2024-518509-17-00
Medical University Of GdanskAcute ischemic stroke
Start: 2022-01-10Target: 300Updated: 2024-12-09
CLASP MS: The study evaluating the efficacy and safety of Polish cladribine in the treatment of patients with secondary progressive multiple sclerosis - a phase 2, randomized, double-blind, placebo-controlled trial.
Not yet recruitingCTIS2024-516992-33-02
Instytut Psychiatrii I NeurologiiMultiple sclerosis secondary progressive form
Target: 188Updated: 2025-01-30
Comparison of treatment efficacy in the patients with Systemic sclerOsis: dapagliFlozin vs. Tocilizumab – a randomized head to head study
WithdrawnCTIS2025-523714-92-00
Centrum Medyczne Ksztalcenia PodyplomowegoSystemic Sclerosis
Target: 80Updated: 2025-12-15

Phase 3

Phase 4