rolofylline

DRUG4 trials

Sponsors

NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA), Merck Sharp & Dohme LLC

Conditions

Heart FailureHeart Failure, Congestive

Phase 2

Hemodynamic Effects of Rolofylline in the Treatment of Patients With Heart Failure (7418-503)

CompletedNCT00729222

Merck Sharp & Dohme LLCHeart Failure

Start: 2008-11-30End: 2009-03-31Updated: 2015-10-20

Phase 3

PROTECT-1: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function

CompletedNCT00328692

NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)Heart Failure, Congestive

Start: 2006-08-31End: 2009-07-31Updated: 2009-10-09

PROTECT-2: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function

CompletedNCT00354458

NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)Heart Failure, Congestive

Start: 2006-10-31End: 2009-07-31Updated: 2009-10-09

Placebo-Controlled Randomized Study of KW-3902 for Subjects Hospitalized With Worsening Renal Function and Heart Failure Requiring IV Therapy

CompletedNCT00443690

NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)Heart Failure, Congestive

Start: 2007-08-31End: 2009-01-31Target: 480Updated: 2009-02-20

Related Papers

Prognostic Significance of Creatinine Increases During an Acute Heart Failure Admission in Patients With and Without Residual Congestion

Circulation Heart Failure2018-05-0175 citations

Biomarker Profiles of Acute Heart Failure Patients With a Mid-Range Ejection Fraction.

2017-06-1478 citations

Associations of Body Mass Index With Laboratory and Biomarkers in Patients With Acute Heart Failure

Circulation Heart Failure2017-01-0115 citations

Blood urea nitrogen-to-creatinine ratio in the general population and in patients with acute heart failure

Heart2016-09-22109 citations

Hypochloremia, Diuretic Resistance, and Outcome in Patients With Acute Heart Failure

Circulation Heart Failure2016-08-01141 citations

Acute heart failure in the young: Clinical characteristics and biomarker profiles

International Journal of Cardiology2016-07-0616 citations

Combining Diuretic Response and Hemoconcentration to Predict Rehospitalization After Admission for Acute Heart Failure

Circulation Heart Failure2016-06-0142 citations

Predictors of Postdischarge Outcomes From Information Acquired Shortly After Admission for Acute Heart Failure

Circulation Heart Failure2013-11-27122 citations

Renal Function Trajectories and Clinical Outcomes in Acute Heart Failure

Circulation Heart Failure2013-11-2763 citations

Impact of serial troponin release on outcomes in patients with acute heart failure: analysis from the PROTECT pilot study.

2011-09-0670 citations

Effects of the adenosine A1 receptor antagonist rolofylline on renal function in patients with acute heart failure and renal dysfunction: results from PROTECT (Placebo-Controlled Randomized Study of the Selective Adenosine A1 Receptor Antagonist Rolofylline for Patients Hospitalized with Acute Decompensated Heart Failure and Volume Overload to Assess Treatment Effect on Congestion and Renal Function).

2011-05-01100 citations

Rolofylline, an adenosine A1-receptor antagonist, in acute heart failure.

2010-10-01376 citations