RO7790121
Sponsors
F. Hoffmann-La Roche AG, Hoffmann-La Roche
Conditions
Atopic DermatitisCrohn's diseaseMASHModerate to Severe Atopic Dermatitis (AD)Moderate to Severe Rheumatoid Arthritis (RA)Moderately to Severely Active Crohn's Disease (CD)Moderately to Severely Active Ulcerative Colitis (UC)moderate to severe rheumatoid arthritis (RA)
Phase 1
Phase 2
A PHASE 2, MULTI-CENTER, DOUBLE-BLIND, TWO-ARM STUDY OF SUBCUTANEOUS RO7790121 FOR THE TREATMENT OF SUBJECTS WITH MODERATE TO SEVERE ACTIVE CROHN’S DISEASE
RecruitingCTIS2023-504265-23-00
Start: 2023-10-23Target: 70Updated: 2025-11-21
A Phase II, Multicenter, Double-Blind, Placebo-Controlled, Study to Assess the Efficacy and Safety of RO7790121 in Patients with Moderate to Severe Atopic Dermatitis
RecruitingCTIS2024-515494-95-00
Start: 2025-05-26Target: 71Updated: 2026-01-27
An Extension Study to Evaluate the Long-Term Safety and Efficacy of Afimkibart (RO7790121) in Patients with Atopic Dermatitis who Participated in Previous Afimkibart Clinical Trials
Not yet recruitingCTIS2025-520771-59-00
Target: 49Updated: 2025-11-26
A Phase II, Multicenter, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of RO7790121 in Patients with Moderate to Severe Rheumatoid Arthritis who have an Inadequate Response or Intolerance to TNF and/or JAK Inhibitors
RecruitingCTIS2025-521034-28-00
Start: 2025-12-05Target: 63Updated: 2026-01-26
An Extension Study to Evaluate the Long-Term Safety and Efficacy of Afimkibart (RO7790121) in Patients with Rheumatoid Arthritis who Participated in Previous Afimkibart Clinical Trials
Not yet recruitingCTIS2025-523579-47-00
Target: 12Updated: 2026-05-28
Phase 3
A PHASE III, MULTICENTER, DOUBLE-BLIND, PLACEBO-CONTROLLED, TREAT-THROUGH STUDY TO ASSESS THE EFFICACY AND SAFETY OF INDUCTION AND MAINTENANCE THERAPY WITH RO7790121 IN PATIENTS WITH MODERATELY TO SEVERELY ACTIVE ULCERATIVE COLITIS
Active, not recruitingCTIS2024-513014-35-00
Start: 2024-11-13Target: 348Updated: 2025-12-15
A Phase III, Multicenter, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Induction Therapy with RO7790121 in Patients with Moderately to Severely Active Ulcerative Colitis
RecruitingCTIS2024-513015-27-00
Start: 2025-01-09Target: 217Updated: 2025-12-19
A Phase III, Multicenter, Double-Blind, Placebo Controlled, Treat-Through Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy with RO7790121 in Patients with Moderately to Severely Active Crohn's Disease
RecruitingCTIS2024-513053-69-00
Start: 2025-04-16Target: 348Updated: 2026-01-12
A Phase III, Multicenter, Double-Blind, Placebo Controlled Study to Assess the Efficacy and Safety of Induction Therapy with RO7790121 in Patients with Moderately to Severely Active Crohn's Disease
RecruitingCTIS2024-513054-30-00
Start: 2025-04-16Target: 225Updated: 2026-01-20