RO7247669
Sponsors
F. Hoffmann-La Roche AG, Hoffmann-La Roche, Hoffmann La Roche
Conditions
Advanced liver cancersCancerEsophageal Squamous Cell CarcinomaHepatocellular Carcinoma (Morpheus-Neo HCC)MelanomaMetastatic MelanomaNon-small Cell Lung CancerPreviously Untreated Locally Advanced or Metastatic Urothelial Cancer
Phase 1
Dose Escalation Study of a PD1-LAG3 Bispecific Antibody in Patients With Advanced and/or Metastatic Solid Tumors
Active, not recruitingNCT04140500
Start: 2019-11-11End: 2027-06-30Updated: 2026-03-18
A PHASE IB/II, OPEN-LABEL, MULTICENTER, RANDOMIZED PLATFORM STUDY EVALUATING THE EFFICACY AND SAFETY OF NEOADJUVANT IMMUNOTHERAPY COMBINATIONS IN PATIENTS WITH SURGICALLY RESECTABLE HEPATOCEULLULAR CARCINOMA (MORPHEUS-NEO HCC)
CompletedCTIS2022-502840-11-00
Start: 2023-11-28End: 2025-10-23Target: 55Updated: 2025-12-08
A PHASE Ib/II, OPEN-LABEL, MULTICENTER, RANDOMIZED UMBRELLA STUDY EVALUATING THE EFFICACY AND SAFETY OF MULTIPLE IMMUNOTHERAPY-BASED TREATMENT COMBINATIONS IN PATIENTS WITH ADVANCED LIVER CANCERS (MORPHEUS LIVER)
Not yet recruitingCTIS2023-506611-17-00
Target: 29Updated: 2025-12-04
Phase 2
A Study of RO7121661 and RO7247669 Compared With Nivolumab in Participants With Advanced or Metastatic Squamous Cell Carcinoma of the Esophagus
Active, not recruitingPACTR202106740461845
Start: 2021-06-30Target: 255Updated: 2026-01-27
A Study of Multiple Doses of RO7247669 in Participants With Previously Untreated Unresectable or Metastatic Melanoma
CompletedNCT05419388
Start: 2022-08-15End: 2025-11-27Updated: 2026-02-04
A Randomized, Open-Label, Multicenter, Phase II Study of Multiple Doses of RO7247669 in Participants with Previously Untreated Unresectable or Metastatic Melanoma
CompletedCTIS2023-505672-30-00
Start: 2023-02-10End: 2025-09-30Target: 37Updated: 2025-10-06
A Phase II, Randomized, Multicenter, Open-Label, Controlled Study of Tobemstomig Alone or in Combination With Tiragolumab Versus Atezolizumab in Patients With Previously Untreated Locally Advanced or Metastatic Urothelial Cancer Who Are Ineligible for Platinum-Containing Chemotherapy
Active, not recruitingCTIS2023-504027-78-00
Start: 2023-01-13Target: 150Updated: 2025-10-31