RMC-9805
Sponsors
Revolution Medicines Inc., Revolution Medicines, Inc., Tango Therapeutics, Inc.
Conditions
Advanced Solid TumorsCRCColorectal CancerColorectal Cancer (CRC)Gastrointestinal CancerKRAS G12C-mutated Solid Tumors, Lung CancerKRAS, NRAS, HRAS-mutated NSCLCLung Cancer
Phase 1
Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors
RecruitingNCT06040541
Start: 2023-09-07End: 2027-04-30Target: 604Updated: 2026-06-03
Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC
RecruitingNCT06162221
Start: 2024-01-18End: 2028-12-01Target: 616Updated: 2026-10-19
Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
RecruitingNCT06445062
Start: 2024-05-24End: 2030-03-30Target: 1130Updated: 2026-09-22
Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients
RecruitingNCT06922591
Start: 2025-05-31End: 2027-12-01Target: 183Updated: 2026-10-23
A Phase 1/2 Open-Label, Multicenter Study of RAS(ON) inhibitors in Combination with Ivonescimab with or without Other Anti-Cancer Agents in Patients with Solid Tumors
Not yet recruitingCTIS2025-524623-50-00
Target: 55Updated: 2026-06-30
Phase 2
A Phase 2, Open-Label, Multicenter Study of Zoldonrasib(RMC-9805) in Previously Treated Patients with RAS G12DMutant
Non-Small Cell Lung Cancer (NSCLC) – Subprotocol D
RecruitingCTIS2025-521681-10-00
Start: 2025-10-02Target: 84Updated: 2025-12-11
A Phase 1b/2 Open-Label, Multicenter Study of RMC-9805 with or without RMC-6236, in Combination with Other Anticancer Agents, in Patients with RAS G12D-Mutated Non-Small Cell Lung Cancer (NSCLC) – Subprotocol C
RecruitingCTIS2025-521147-21-00
Start: 2025-10-08Target: 130Updated: 2026-01-14
Phase 3
A Phase 3, Randomized, Double-blind, Placebo-controlled Study of Investigator Choice of Chemotherapy (modified FOLFIRINOX or Gemcitabine plus Nab-paclitaxel) with or without Zoldonrasib (RMC-9805) as First-line Treatment in Patients with Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma (RASolute 305)
Not yet recruitingCTIS2025-524928-21-00
Target: 85Updated: 2026-08-25
A Phase 3, Randomized, Open-Label Study of Zoldonrasib (RMC-9805) Plus Daraxonrasib (RMC-6236) Versus Gemcitabine and Nab-Paclitaxel as First-Line Treatment in Patients with Metastatic KRAS G12D-Mutated Pancreatic Adenocarcinoma (RASolute 309)
Not yet recruitingCTIS2025-524969-24-00
Target: 56Updated: 2026-10-13