RLX030

DRUG4 trials

Sponsors

Novartis Pharmaceuticals

Conditions

Acute Heart FailureChronic Heart Failure (CHF)Pre-eclampsia

Phase 2

Hemodynamic Responses to RLX030 Infusion in Subjects With Acute Heart Failure

CompletedNCT01543854

Novartis PharmaceuticalsAcute Heart Failure

Start: 2012-03-31End: 2013-01-31Updated: 2014-08-05

Renal Hemodynamic Effects of RLX030A in Subjects With Chronic Heart Failure (CHF)

CompletedNCT01546532

Novartis PharmaceuticalsChronic Heart Failure (CHF)

Start: 2012-02-29End: 2012-12-31Updated: 2020-12-19

Safety and Efficacy of RLX030 in Pregnant Women With Pre- Eclampsia

TerminatedNCT01566630

Novartis PharmaceuticalsPre-eclampsia

Start: 2013-05-31End: 2014-08-31Updated: 2015-11-05

Phase 3

Efficacy, Safety and Tolerability of Serelaxin When Added to Standard Therapy in AHF

CompletedNCT01870778

Novartis PharmaceuticalsAcute Heart Failure

Start: 2013-10-02End: 2017-02-01Updated: 2018-03-30

Related Papers

Clinical Presentation, Biomarker Trajectories, and Outcomes in Women and Men Hospitalized for Acute Heart Failure.

2025-08-211 citations

Decongestion and Outcomes in Patients Hospitalized for Acute Heart Failure: Insights From the RELAX-AHF-2 Trial.

2024-11-275 citations

Blood Pressure Drops During Hospitalization for Acute Heart Failure Treated With Serelaxin: A Patient-Level Analysis of 4 Randomized Controlled Trials

Circulation Heart Failure2022-02-216 citations

Association of Early Blood Pressure Decrease and Renal Function With Prognosis in Acute Heart Failure

JACC Heart Failure2021-10-0822 citations

Cause of Death in Patients With Acute Heart Failure

JACC Heart Failure2020-11-1122 citations

Effects of Serelaxin in Patients with Acute Heart Failure

New England Journal of Medicine2019-08-21253 citations

A double blind, randomised, placebo-controlled trial to evaluate the efficacy of metformin to treat preterm pre-eclampsia (PI2 Trial): study protocol

BMJ Open2019-04-0146 citations

Serelaxin in Addition to Standard Therapy in Acute Heart Failure: Rationale and Design of the RELAX-AHF-2 Study

European Journal of Heart Failure2017-04-28121 citations

Renal Hemodynamic Effects of Serelaxin in Patients With Chronic Heart Failure

Circulation Heart Failure2014-10-0748 citations

A randomized, double-blind, placebo-controlled, multicentre study to assess haemodynamic effects of serelaxin in patients with acute heart failure

European Heart Journal2013-11-18118 citations