Rixathon 500 mg concentrate for solution for infusion
Sponsors
Amsterdam UMC, Deutsches Zentrum Fuer Neurodegenerative Erkrankungen e.V., Alexion Pharmaceuticals Inc., UZ Leuven, Ospedale Pediatrico Bambino Gesu'
Conditions
Chronic inflammatory demyelinating polyneuropathy (CIDP)Complicated forms of idiopathic steroid-sensitive nephrotic syndrome (SSNS)HYPOPHOSPHATASIAMultiple sclerosisPatients with a diagnosis of IgAV according to Chapel Hill Consensus Conference definitions. Patients will require having a biopsy-proven diagnosis of IgAV.Relapsed/Refractory Diffuse Large B-Cell Lymphoma (RR DLBCL)Rheumatoid ArthritisRheumatoid arthritis
Phase 1
Phase 2
B-cell depletion for the treatment of patients with amyotrophic lateral sclerosis (ALS) - A Randomized, Double-blind, Placebo controlled Pilot Study in Patients with Amyotrophic Lateral Sclerosis for the Evaluation of Efficacy and Safety of B-Cell Depletion with Rituximab (ABCD)
RecruitingCTIS2022-502743-35-00
Start: 2024-04-22Target: 52Updated: 2025-12-19
The MEMORINEPH study: Memory B cell level-based tailored treatment with Rixathon in children with complicated forms of steroid-sensitive Nephrotic syndrome
WithdrawnCTIS2024-511214-20-00
Target: 80Updated: 2024-10-25
A Phase 2/3, Multicenter Randomized Study of Rituximab-Gemcitabine-
Dexamethasone-Platinum (R-GDP) With or Without Selinexor in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma (RR DLBCL).
Active, not recruitingCTIS2024-513616-95-00
Start: 2020-12-22Target: 60Updated: 2025-10-02
Evaluation of Glucocorticoids plus Rituximab Compared to Glucocorticoids Plus Placebo for the Treatment of Patients With Newly-Diagnosed or Relapsing IgA vasculitis: A Prospective, randomized, controlled, double-blind study
RecruitingCTIS2024-516052-17-01
Start: 2026-01-27Target: 72Updated: 2024-11-28
Phase 3
Danish non-inferiority study of ocrelizumab and rituximab in MS: A randomized study comparing the efficacy of ocrelizumab
and rituximab in active multiple sclerosis
Active, not recruitingCTIS2024-514287-84-00
Start: 2021-04-28Target: 600Updated: 2024-08-05
Rituximab-induced remission in CIDP (ReCIX study)
RecruitingCTIS2024-512506-25-00
Start: 2024-10-07Target: 102Updated: 2025-10-17
Phase 4
Noisy Rebels; Non-inferiority study of rituximab compared to ocrelizumab in relapsing MS
Active, not recruitingCTIS2022-502664-21-00
Start: 2023-05-01Target: 200Updated: 2025-10-14
Tapering of Rituximab Based on Interval Prolongation Compared to Disease Activity-Guided Dose Reduction in Patients with Rheumatoid Arthritis: The RITUXERA Trial.
RecruitingCTIS2023-506638-59-01
Start: 2024-01-09Target: 134Updated: 2025-08-27
An Interventional, Prospective Open-Label Study of Immunosuppressive Therapies to Mitigate Immune-Mediated Loss of Therapeutic Response to Asfotase Alfa (STRENSIQ®) for Hypophosphatasia (RESTORE)
CompletedCTIS2022-502793-17-00
End: 2025-08-08Target: 1Updated: 2024-09-19