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Rixathon 500 mg concentrate for solution for infusion

DRUG10 trials

Sponsors

Amsterdam UMC, Deutsches Zentrum Fuer Neurodegenerative Erkrankungen e.V., Alexion Pharmaceuticals Inc., UZ Leuven, Ospedale Pediatrico Bambino Gesu'

Conditions

Chronic inflammatory demyelinating polyneuropathy (CIDP)Complicated forms of idiopathic steroid-sensitive nephrotic syndrome (SSNS)HYPOPHOSPHATASIAMultiple sclerosisPatients with a diagnosis of IgAV according to Chapel Hill Consensus Conference definitions. Patients will require having a biopsy-proven diagnosis of IgAV.Relapsed/Refractory Diffuse Large B-Cell Lymphoma (RR DLBCL)Rheumatoid ArthritisRheumatoid arthritis

Phase 1

Phase 2

B-cell depletion for the treatment of patients with amyotrophic lateral sclerosis (ALS) - A Randomized, Double-blind, Placebo controlled Pilot Study in Patients with Amyotrophic Lateral Sclerosis for the Evaluation of Efficacy and Safety of B-Cell Depletion with Rituximab (ABCD)
RecruitingCTIS2022-502743-35-00
Deutsches Zentrum Fuer Neurodegenerative Erkrankungen e.V.Sporadic Amyotrophic Lateral Sclerosis
Start: 2024-04-22Target: 52Updated: 2025-12-19
The MEMORINEPH study: Memory B cell level-based tailored treatment with Rixathon in children with complicated forms of steroid-sensitive Nephrotic syndrome
WithdrawnCTIS2024-511214-20-00
Ospedale Pediatrico Bambino Gesu'Complicated forms of idiopathic steroid-sensitive nephrotic syndrome (SSNS)
Target: 80Updated: 2024-10-25
A Phase 2/3, Multicenter Randomized Study of Rituximab-Gemcitabine- Dexamethasone-Platinum (R-GDP) With or Without Selinexor in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma (RR DLBCL).
Active, not recruitingCTIS2024-513616-95-00
Karyopharm Therapeutics Inc.Relapsed/Refractory Diffuse Large B-Cell Lymphoma (RR DLBCL)
Start: 2020-12-22Target: 60Updated: 2025-10-02
Evaluation of Glucocorticoids plus Rituximab Compared to Glucocorticoids Plus Placebo for the Treatment of Patients With Newly-Diagnosed or Relapsing IgA vasculitis: A Prospective, randomized, controlled, double-blind study
RecruitingCTIS2024-516052-17-01
Hospital FochPatients with a diagnosis of IgAV according to Chapel Hill Consensus Conference definitions. Patients will require having a biopsy-proven diagnosis of IgAV.
Start: 2026-01-27Target: 72Updated: 2024-11-28

Phase 3

Phase 4

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