Rituximab (R)

DRUG16 trials

Sponsors

National Cancer Institute (NCI), Hoffmann-La Roche, The Lymphoma Academic Research Organisation, InnoCare Pharma Inc., Institute of Hematology & Blood Diseases Hospital, China

Conditions

B-Cell LymphomaDiffuse Large B-cell LymphomaDouble Expressor DLBCLEBV Infection After Allogenic HSCTGranulomatosis With PolyangiitisLarge B-Cell Lymphoma (LBCL)Lymphoma, Mantle CellMantle Cell Lymphoma

Phase 1

A Study of Glofitamab in Combination With Rituximab or Obinutuzumab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP), or Polatuzumab Vedotin Plus Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone (CHP) in Participants With Non-Hodgkin Lymphomas or With DLBCL

CompletedNCT03467373

Hoffmann-La RocheB-Cell Lymphoma, Non-Hodgkin Lymphoma

Start: 2018-03-13End: 2024-12-02Updated: 2025-01-17

Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ICP-248 as Monotherapy or in Combination With Anti-CD20 Monoclonal Antibody in Mature B-cell Malignancies

RecruitingNCT06351527

InnoCare Pharma Inc.Mature B-cell Malignancies

Start: 2024-04-23End: 2027-10-25Target: 78Updated: 2025-06-19

R-CMOP in Patients With Newly Diagnosed Diffuse Large B-cell Lymphoma

RecruitingNCT06594640

Institute of Hematology & Blood Diseases Hospital, ChinaDiffuse Large B-cell Lymphoma

Start: 2024-05-30End: 2027-07-30Target: 108Updated: 2026-06-10

Phase Ib/II Study of Polatuzumab Vedotin in Combination With Rituximab and Chidamide in Newly Diagnosed Elderly Patients With Double-Expressor DLBCL

Not yet recruitingNCT07415980

Sun Yat-sen UniversityDouble Expressor DLBCL

Start: 2026-04-01End: 2031-04-01Target: 68Updated: 2026-02-17

Phase 2

EPOCH-R Chemotherapy Plus Bortezomib to Treat Mantle Cell Lymphoma

CompletedNCT00114738

National Cancer Institute (NCI)Lymphoma, Mantle Cell, Mantle Cell Lymphoma

Start: 2005-06-15End: 2022-08-11Updated: 2022-10-10

ZR-MTX for PIOL Phase II Trial

RecruitingNCT06973811

Peking Union Medical College HospitalPrimary Intraocular Lymphoma

Start: 2024-10-10End: 2029-10-30Target: 47Updated: 2026-09-04

Orelabrutinib Combined With Teniposide, Rituximab and Methotrexate for Newly Diagnosed PCNSL

RecruitingNCT07185373

Huashan HospitalPrimary Central Nervous System Lymphoma

Start: 2025-10-01End: 2029-07-30Target: 215Updated: 2026-08-19

Orelabrutinib and Rituximab With Optional Autologous Hematopoietic Stem Cell Transplantation in MCL Treatment

RecruitingNCT07199296

Ruijin HospitalMantle Cell Lymphoma (MCL)

Start: 2025-07-01End: 2028-07-01Target: 45Updated: 2025-09-30

Orelabrutinib Plus Low-Dose Radiotherapy Or Rituximab For Ocular Adnexal MALT Lymphoma

Active, not recruitingNCT07247383

Second Affiliated Hospital, School of Medicine, Zhejiang UniversityMarginal Zone Lymphoma(MZL), Marginal Zone Lymphoma of Ocular Adnexal

Start: 2025-09-19End: 2028-12-31Target: 39Updated: 2025-11-25

Orelabrutinib Plus Lisaftoclax and Rituximab in Untreated Mantle Cell Lymphoma With High-Risk Disease

RecruitingNCT07272499

Ruijin HospitalMantle Cell Lymphoma (MCL)

Start: 2025-09-10End: 2028-09-10Target: 25Updated: 2026-07-28

PD-1 Inhibitor Combined With Rituximab, Methotrexate, and Orelabrutinib (PD-1i+RMO) for Newly Diagnosed PCNSL and SCNSL.

RecruitingNCT07410520

The First Affiliated Hospital with Nanjing Medical UniversityPrimary Central Nervous System Lymphoma (PCNSL), Secondary Central Nervous System Lymphoma (SCNSL)

Start: 2026-02-07End: 2029-12-31Target: 50Updated: 2026-02-13

AI-Driven Treatment Strategy vs ZR2 in Older Treatment-naive Patients With LBCL

Not yet recruitingNCT07717177

Ruijin HospitalLarge B-Cell Lymphoma (LBCL)

Start: 2026-06-30End: 2029-12-31Target: 112Updated: 2026-07-21

Phase 3

Mosunetuzumab-Lenalidomide Versus Investigator Choices in Patients With Relapsed or Refractory Marginal Zone Lymphoma

RecruitingNCT06006117

The Lymphoma Academic Research OrganisationMarginal Zone Lymphoma

Start: 2023-09-05End: 2032-09-01Target: 260Updated: 2026-06-15

Safe Effective Therapy With Low-Dose Glucocorticoid in ANCA-Associated Vasculitis (SAFE-LOW)

RecruitingNCT06983821

Ottawa Hospital Research InstituteGranulomatosis With Polyangiitis, Microscopic Polyangiitis (MPA)

Start: 2025-11-10End: 2029-02-01Target: 36Updated: 2026-01-30

Phase 4

Rituximab Versus Ravulizumab, Inebilizumab, Satralizumab, and Eculizumab in NMOSD

Not yet recruitingNCT07010302

Massachusetts General HospitalNMOSD

Start: 2026-08-01End: 2030-05-01Target: 540Updated: 2026-08-31

Unknown Phase

Prevention of Epstein-Barr Virus Reactivation With the ATG-based Haploidentical Protocol Combined With Rituximab in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

RecruitingNCT07693881

Nanfang Hospital, Southern Medical UniversityEBV Infection After Allogenic HSCT

Start: 2026-07-01End: 2029-12-31Target: 106Updated: 2026-07-23

Related Papers

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British Journal of Haematology2026-08-17

Efficacy and tolerability of mesutoclax monotherapy in Relapsed/Refractory Mantle Cell Lymphoma patients: High remission rates even in prior BTKi-refractory patients

Blood2025-11-03

Preclinical advances in glofitamab combinations: a new frontier for non-Hodgkin lymphoma.

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Glofitamab + Pola-R-CHP in patients with previously untreated diffuse large B-cell lymphoma (DLBCL): Results from a phase Ib study.

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Circulating tumor DNA predicts therapeutic outcome in mantle cell lymphoma

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