Riociguat

DRUG16 trials

Sponsors

Assistance Publique Hopitaux De Paris, Richard Moon, University of Cincinnati, Mark Gladwin, Assistance Publique - Hôpitaux de Paris

Conditions

Altitude SicknessCTEPHChronic Thromboembolic Pulmonary HypertensionDigital UlcersHeadacheHealthyHeart Failure With Normal Ejection FractionHypertension, Pulmonary

Phase 1

A 2-part Study to Investigate the Effect of Macitentan in Healthy Male Participants

CompletedNCT04211272

ActelionHealthy

Start: 2020-01-14End: 2021-04-19Updated: 2025-03-30

Phase 2

A Multi-Center Study of Riociguat in Patients With Sickle Cell Diseases

CompletedNCT02633397

Mark GladwinSickle Cell Disease

Start: 2017-04-11End: 2022-05-04Updated: 2023-07-19

Pharmacodynamic Effects of Riociguat in Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction

CompletedNCT02744339

Medical University of ViennaHeart Failure With Normal Ejection Fraction, Hypertension, Pulmonary

Start: 2016-03-31End: 2020-09-30Updated: 2020-11-04

Riociguat in Scleroderma Associated Digital Ulcers

CompletedNCT02915835

Dinesh Khanna, MD, MSDigital Ulcers, Scleroderma

Start: 2016-09-30End: 2018-07-24Updated: 2019-09-24

Riociguat in Patients With Operable CTEPH Prior to Pulmonary Endarterectomy (PEA Bridging Study)

TerminatedNCT03273257

International CTEPH AssociationChronic Thromboembolic Pulmonary Hypertension, CTEPH

Start: 2018-08-17End: 2020-05-05Updated: 2021-06-22

Networked Drug REpurposing for Mechanism-based neuroPrOtection in Acute Ischaemic STROKE

Maastricht UniversityIschemic Stroke, Acute

Start: 2022-09-05End: 2024-04-30Target: 28Updated: 2023-10-19

DIRECTION- Discontinuation versus continuation of riociguat monotherapy in chronic thromboembolic pulmonary hypertension successfully treated with balloon pulmonary angioplasty

Not yet recruitingCTIS2026-525351-81-00

Assistance Publique Hopitaux De Parischronic thromboembolic pulmonary hypertension

Target: 150Updated: 2026-08-25

Phase 3

Effects of Combination Medical Therapy Followed by BPA on Right Ventricular-PA Coupling and Hemodynamics in CTEPH

TerminatedNCT05140525

Dr Sudarshan RajagopalCTEPH

Start: 2025-01-27End: 2026-05-01Updated: 2026-09-03

Riociguat-Discontinue Effects on Right HEART in CTEPH (RED-HEART)

RecruitingNCT06922240

Suqiao YangChronic Thromboembolic Pulmonary Hypertension

Start: 2025-03-21End: 2027-10-31Target: 68Updated: 2025-04-30

Phase 4

Efficacy Study of Riociguat and Its Effects on Exercise Performance and Pulmonary Artery Pressure at High Altitude

CompletedNCT02024386

Richard MoonAltitude Sickness, Hypertension, Pulmonary

Start: 2014-01-31End: 2015-12-31Updated: 2017-04-12

Riociguat for Sarcoidosis Associated Pulmonary Hypertension

University of CincinnatiSarcoidosis

Start: 2015-04-30End: 2018-10-31Target: 60Updated: 2015-12-09

Effects of Riociguat on RIght VEntricular Size and Function in PAH and CTEPH

TerminatedNCT04954742

Heidelberg UniversityChronic Thromboembolic Pulmonary Hypertension, Primary Pulmonary Arterial Hypertension

Start: 2022-04-13End: 2025-08-13Updated: 2026-06-17

Pulmonary Hypertension: Intensification and Personalisation of Combination Rx

Active, not recruitingNCT05825417

Sheffield Teaching Hospitals NHS Foundation TrustPulmonary Arterial Hypertension

Start: 2023-06-14End: 2028-01-01Target: 70Updated: 2026-08-07

Unknown Phase

Riociguat Versus Balloon Pulmonary Angioplasty in Non-operable Chronic thromboEmbolic Pulmonary Hypertension

CompletedNCT02634203

Assistance Publique - Hôpitaux de ParisChronic Thromboembolic Pulmonary Hypertension

Start: 2016-01-19End: 2020-01-27Updated: 2021-01-26

Sleep-Disordered Breathing in Chronic Thromboembolic Pulmonary Hypertension

CompletedNCT03074539

Medical University of ViennaChronic Thromboembolic Pulmonary Hypertension, Sleep Disordered Breathing

Start: 2017-02-01End: 2022-12-31Updated: 2023-03-14

Effect of Riocigaut on Cerebral Vasodilation and Headache Induction in Healthy Volunteers

CompletedNCT05582811

Danish Headache CenterHeadache

Start: 2022-10-26End: 2023-06-01Updated: 2024-01-05

Related Papers

Effects of riociguat on right ventricular size and function in pulmonary arterial hypertension (RIVER II): a prospective, phase IV study

Respiratory Research2026-07-28

The CYB5R3 T117S Missense Variant is Associated with Attenuated Riociguat Efficacy in Sickle Cell Disease

Blood2026-07-08

Synergistic Network Pharmacology: Preclinical Validation and Clinical Safety in Acute Ischemic Stroke

Journal of the American Heart Association2025-05-152 citations

Effect of Balloon Pulmonary Angioplasty and Riociguat on Right Ventricular Afterload and Function in CTEPH: Insights From the RACE Trial

Circulation Cardiovascular Interventions2025-02-015 citations

Riociguat in patients with sickle cell disease and hypertension or proteinuria (STERIO-SCD): a randomised, double-blind, placebo controlled, phase 1-2 trial.

2024-03-275 citations

Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension: Clinical Outcomes.

2023-04-053 citations

Medical bridging therapy before pulmonary endarterectomy?

13.01 - Pulmonary hypertension2022-09-041 citations

Balloon pulmonary angioplasty versus riociguat for the treatment of inoperable chronic thromboembolic pulmonary hypertension (RACE): a multicentre, phase 3, open-label, randomised controlled trial and ancillary follow-up study.

2022-08-01134 citations

Balloon pulmonary angioplasty combined with riociguat for the treatment of inoperable chronic thromboembolic pulmonary hypertension (PRACTICE study): study protocol for a randomized controlled trial.

2021-12-271 citations

Riociguat for Sarcoidosis-Associated Pulmonary Hypertension: Results of a 1-Year Double-Blind, Placebo-Controlled Trial.

2021-08-0434 citations

Multicentre randomised controlled trial of balloon pulmonary angioplasty and riociguat in patients with chronic thromboembolic pulmonary hypertension: protocol for the MR BPA study

BMJ Open2020-02-0120 citations

A multicenter randomized, double-blind, placebo-controlled pilot study to assess the efficacy and safety of riociguat in systemic sclerosis-associated digital ulcers.

2019-09-0319 citations

Balloon pulmonary angioplasty: does it have a role in CTED?

Pulmonary Circulation2018-01-0110 citations