Repotrectinib
Sponsors
Instituto Oncológico Dr Rosell, Memorial Sloan Kettering Cancer Center, Bristol-Myers Squibb, MedSIR, M.D. Anderson Cancer Center
Conditions
Advanced CancerBrain MetastasesCarcinoma, Non-Small-Cell LungHealthy VolunteersHepatic ImpairmentHormone Receptor-positive Human Epidermal Growth Factor 2-negativeMetastatic Invasive LObular CarcinomaMetastatic Solid Tumor
Phase 1
Phase I Study of Repotrectinib and Osimertinib in NSCLC Patients
RecruitingNCT04772235
Start: 2022-02-11End: 2026-06-30Target: 32Updated: 2024-04-03
A Study of Repotrectinib in Combination With Chemotherapy in Children and Young Adults With Solid Tumor Cancer
RecruitingNCT05004116
Start: 2021-08-09End: 2028-08-01Target: 77Updated: 2026-06-04
A Study to Assess the Drug Levels of Repotrectinib in Healthy Participants and Participants With Moderate and Severe Hepatic Impairment
CompletedNCT06352528
Start: 2024-04-29End: 2025-09-16Updated: 2025-10-06
A Study to Assess the Effect of Voriconazole and Quinidine on the Pharmacokinetics of a Single Dose of Repotrectinib in Healthy Participants
CompletedNCT06493409
Start: 2024-08-26End: 2024-12-07Updated: 2025-08-22
Study to Evaluate the Effect of Repotrectinib on the Drug Levels of Transporter and CYP P450 Probe Substrates in Healthy Adult Participants
CompletedNCT07223671
Start: 2025-12-31End: 2026-03-19Updated: 2026-03-27
Phase 2
Repotrectinib in ROS1-positive Non-small Cell Lung Cancer Patients With Active Brain Metastasis
RecruitingNCT06315010
Start: 2025-06-27End: 2028-04-01Target: 20Updated: 2026-09-09
Phase II Study of REPotrectinib With or Without Fulvestrant in Patients With Hormone Receptor-positive Human Epidermal Growth Factor 2-negative Metastatic Invasive LObular Carcinoma Who Received a Prior Endocrine Therapy in Combination With Cyclin-dependent Kinase 4 and 6 Inhibitor (REPLOT Trial)
TerminatedNCT06408168
Start: 2024-08-08End: 2025-12-08Updated: 2026-01-05
Phase II Efficacy Study of Repotrectinib in Frail and/or Elderly Patients With ROS1-rearranged Advanced NSCLC
RecruitingNCT06552234
Start: 2024-10-01End: 2031-09-01Target: 30Updated: 2026-07-07
Phase 3
Unknown Phase
Expanded Access for Repotrectinib
NCT05926232
Updated: 2023-07-03
Repotrectinib Post-Marketing Surveillance in Korean Patients With ROS1-Positive Non-Small Cell Lung Cancer (NSCLC) or Solid Tumors Harboring a Neurotrophic Tyrosine Receptor Kinase (NTRK) Gene Fusion
Not yet recruitingNCT07599007
Start: 2026-05-24End: 2028-01-31Target: 10Updated: 2026-05-20
Repotrectinib Post-Marketing Surveillance in Pediatric Patients With NTRK Fusion-Positive Tumors in Japan
RecruitingNCT07755826
Start: 2025-11-20End: 2034-04-30Target: 20Updated: 2026-08-10