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Regulatory T cells

BIOLOGICAL6 trials

Sponsors

Nanjing Medical University, Laura Johnston, VTBIO Co. LTD, Thomas Wekerle, University of Erlangen-Nürnberg Medical School

Conditions

Allogeneic Hematopoietic Cell Transplant RecipientAlzheimer DiseaseAutoimmune DiseasesChronic Rejection of Liver TransplantGraft Versus Host DiseaseKidney TransplantationUlcerative Colitis

Phase 1

Safety Study of Using Regulatory T Cells Induce Liver Transplantation Tolerance
NCT01624077
Nanjing Medical UniversityChronic Rejection of Liver Transplant
Start: 2014-12-31End: 2015-12-31Target: 1Updated: 2015-02-24
Phase 1 Infused Donor T Regulatory Cells in Steroid Dependent/Refractory Chronic GVHD
CompletedNCT01911039
Laura JohnstonAllogeneic Hematopoietic Cell Transplant Recipient, Graft Versus Host Disease
Start: 2013-07-31End: 2018-07-31Updated: 2021-09-27
Safety and Efficacy Study of Regulatory T Cells in Treating Autoimmune Hepatitis
NCT02704338
Nanjing Medical UniversityAutoimmune Diseases
Start: 2016-04-30End: 2018-10-31Target: 30Updated: 2016-03-10
A Safety and Tolerability Study of GB301
NCT03865017
VTBIO Co. LTDAlzheimer Disease
Start: 2019-12-01End: 2021-12-01Target: 20Updated: 2019-08-05
Cell Therapy for Immunomodulation in Kidney Transplantation
Active, not recruitingNCT03867617
Thomas WekerleKidney Transplantation
Start: 2019-08-01End: 2028-06-01Updated: 2026-09-11
Autologous Ex Vivo Expanded Regulatory T Cells in Ulcerative Colitis
CompletedNCT04691232
University of Erlangen-Nürnberg Medical SchoolAutoimmune Diseases, Ulcerative Colitis
Start: 2021-02-22End: 2023-05-22Updated: 2023-10-17

Related Papers

Donor bone marrow together with recipient regulatory T cells induces chimerism without irradiation in kidney transplantation
Science Translational Medicine2026-06-17
Optimum timing of antithymocyte globulin in relation to adoptive regulatory T cell therapy
American Journal of Transplantation2023-01-0110 citations
Autologous regulatory T-cell transfer in refractory ulcerative colitis with concomitant primary sclerosing cholangitis
Gut2022-04-1582 citations
Safety and tolerability of a single infusion of autologous ex vivo expanded regulatory T cells in adults with ulcerative colitis (ER-TREG 01): protocol of a phase 1, open-label, fast-track dose-escalation clinical trial
BMJ Open2021-12-0117 citations
A Prospective Controlled Trial to Evaluate Safety and Efficacy of in vitro Expanded Recipient Regulatory T Cell Therapy and Tocilizumab Together With Donor Bone Marrow Infusion in HLA-Mismatched Living Donor Kidney Transplant Recipients (Trex001)
Frontiers in Medicine2021-01-2721 citations