REGN9933
Sponsors
Regeneron Pharmaceuticals Inc., Regeneron Pharmaceuticals
Conditions
Atrial Fibrillation (AF)Healthy VolunteersPeripheral Artery Disease (PAD)Thromboembolic diseaseVenous Thromboembolism
Phase 1
Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of REGN9933 in Adult Healthy Volunteers
CompletedNCT05102136
Start: 2021-10-27End: 2023-04-04Updated: 2023-05-03
Assessment of Gastrointestinal Blood Loss After Receiving Aspirin or Aspirin Plus Rivaroxaban, or Aspirin Plus REGN9933, or Aspirin Plus REGN7508 in Healthy Adult Participants
CompletedNCT06444178
Start: 2024-09-30End: 2025-07-09Updated: 2025-07-16
Phase 2
A Trial to Learn How Well REGN9933 Works for Preventing Blood Clots After Knee Replacement Surgery in Adult Participants
CompletedNCT05618808
Start: 2023-05-24End: 2024-05-27Updated: 2025-08-29
A Phase 2, Multicenter, Randomized, Open-Label, Active-Control Study of REGN9933, a Factor XI Monoclonal Antibody, for Prevention of Venous Thromboembolism after Elective, Unilateral, Total Knee Arthroplasty
CompletedCTIS2022-501470-18-00
Start: 2023-06-26End: 2024-05-27Target: 408Updated: 2024-04-15
A Trial to Learn How Well REGN9933 and REGN7508 Work for Preventing Blood Clots, and How Safe They Are, in Adults Who Have a Peripherally Inserted Central Catheter (PICC)
Active, not recruitingNCT06299111
Start: 2024-09-20End: 2026-06-01Updated: 2026-01-12
A Master Protocol for a Phase 2 Randomized, Double-blind, Placebo-controlled Study of REGN9933 and REGN7508, Monoclonal Antibodies against Factor XI for Prevention of Venous Thromboembolism in Patients with a Peripherally Inserted Central Catheter (ROXI-CATH).
RecruitingCTIS2023-508603-21-00
Start: 2024-09-20Target: 93Updated: 2026-01-26
Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation
RecruitingNCT07175428
Start: 2025-10-20End: 2027-04-21Target: 1200Updated: 2026-03-18
Phase 3
Reducing Adverse Vascular Outcomes With Factor XI Inhibition in Adult Participants With Peripheral Artery Disease
Not yet recruitingNCT07318610
Start: 2026-03-31End: 2029-08-03Target: 7050Updated: 2026-01-06
Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation for Whom Oral Anticoagulation is Unsuitable
Not yet recruitingNCT07430956
Start: 2026-03-18End: 2029-06-26Target: 2628Updated: 2026-02-24