REGN9933
Sponsors
Regeneron Pharmaceuticals Inc., Regeneron Pharmaceuticals
Conditions
Atrial Fibrillation (AF)End-Stage Kidney Disease (ESKD)Healthy VolunteersPeripheral Artery DiseasePeripheral Artery Disease (PAD)Thromboembolic diseaseVenous ThromboembolismVenous Thromboembolism (VTE)
Phase 1
Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of REGN9933 in Adult Healthy Volunteers
CompletedNCT05102136
Start: 2021-10-27End: 2023-04-04Updated: 2023-05-03
Assessment of Gastrointestinal Blood Loss After Receiving Aspirin or Aspirin Plus Rivaroxaban, or Aspirin Plus REGN9933, or Aspirin Plus REGN7508 in Healthy Adult Participants
CompletedNCT06444178
Start: 2024-09-30End: 2025-07-09Updated: 2025-07-16
Study of 3 Monoclonal Antibodies (REGN9933, REGN7508, and REGN9533) in Adult Participants With End-Stage Kidney Disease on Hemodialysis
RecruitingNCT07759167
Start: 2026-09-17End: 2027-04-02Target: 36Updated: 2026-10-06
Phase 2
A Trial to Learn How Well REGN9933 Works for Preventing Blood Clots After Knee Replacement Surgery in Adult Participants
CompletedNCT05618808
Start: 2023-05-24End: 2024-05-27Updated: 2025-08-29
A Phase 2, Multicenter, Randomized, Open-Label, Active-Control Study of REGN9933, a Factor XI Monoclonal Antibody, for Prevention of Venous Thromboembolism after Elective, Unilateral, Total Knee Arthroplasty
CompletedCTIS2022-501470-18-00
Start: 2023-06-26End: 2024-05-27Target: 408Updated: 2024-04-15
A Trial to Learn How Well REGN9933 and REGN7508 Work for Preventing Blood Clots, and How Safe They Are, in Adults Who Have a Peripherally Inserted Central Catheter (PICC)
CompletedNCT06299111
Start: 2024-09-20End: 2026-03-27Updated: 2026-04-13
A Master Protocol for a Phase 2 Randomized, Double-blind, Placebo-controlled Study of REGN9933 and REGN7508, Monoclonal Antibodies against Factor XI for Prevention of Venous Thromboembolism in Patients with a Peripherally Inserted Central Catheter (ROXI-CATH).
RecruitingCTIS2023-508603-21-00
Start: 2024-09-20Target: 93Updated: 2026-01-26
Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation
RecruitingNCT07175428
Start: 2025-10-20End: 2027-04-21Target: 1200Updated: 2026-10-21
Phase 3
Reducing Adverse Vascular Outcomes With Factor XI Inhibition in Adult Participants With Peripheral Artery Disease
RecruitingNCT07318610
Start: 2026-07-10End: 2029-11-16Target: 7050Updated: 2026-10-22
Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation for Whom Oral Anticoagulation is Unsuitable
RecruitingNCT07430956
Start: 2026-04-03End: 2029-06-26Target: 2628Updated: 2026-10-14
Venous Thromboembolism (VTE) Prophylaxis With REGN7508 and REGN9933 in Adult and Adolescent Participants With a Peripherally Inserted Central Catheter (PICC)
RecruitingNCT07697599
Start: 2026-09-07End: 2029-09-18Target: 1908Updated: 2026-09-29
A Master Protocol for a Phase 3, Multicenter, Randomized Study to Evaluate the Efficacy and Safety of REGN7508 and REGN9933, Monoclonal Antibodies Against Factor XI, in Participants with Recent Lower Extremity Revascularization for Symptomatic Peripheral Artery Disease (ROXI-PALISADE)
Not yet recruitingCTIS2025-522954-37-00
Target: 1215Updated: 2026-09-30
A Master Protocol for a Phase 3, Randomized, Multicenter, Double-blind Study to Assess Stroke and Systemic Embolism Prevention with REGN7508 and REGN9933, Monoclonal Antibodies Against Factor XI, versus Placebo in Participants with Atrial Fibrillation for Whom Oral Anticoagulation is Unsuitable (ROXI-INCLINE)
Not yet recruitingCTIS2025-521618-25-00
Target: 237Updated: 2026-09-30