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Recombinant tissue plasminogen activator (rt-PA)

DRUG4 trials

Sponsors

Johns Hopkins University, Washington University School of Medicine, Beijing Chao Yang Hospital, University of Colorado, Denver

Conditions

Cerebral HemorrhageDeep Vein ThrombosisPost Thrombotic SyndromePost-Thrombotic SyndromePostphlebitic SyndromePulmonary EmbolismPulmonary ThromboembolismsVenous Thromboembolism

Phase 2

Intraventricular Rt-PA in Patients With Intraventricular Hemorrhage
CompletedNCT00029315
Johns Hopkins UniversityCerebral Hemorrhage
Start: 2001-09-30End: 2004-09-30Target: 30Updated: 2015-03-25

Phase 3

Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis
CompletedNCT00790335
Washington University School of MedicineDeep Vein Thrombosis, Postphlebitic Syndrome, Post Thrombotic Syndrome +2
Start: 2009-11-30End: 2017-01-31Updated: 2018-03-29
Pediatric High-Risk Deep Venous Thrombosis Lytic Outcomes Trial
WithdrawnNCT02767232
University of Colorado, DenverDeep Vein Thrombosis, Post-Thrombotic Syndrome, Venous Thrombosis
Start: 2018-07-31End: 2023-06-30Updated: 2018-08-10

Phase 4

Low Dose Rt-PA for Acute Normotensive Pulmonary Embolism With RVD
NCT01531829
Beijing Chao Yang HospitalPulmonary Embolism, Pulmonary Thromboembolisms
Start: 2009-07-31End: 2012-12-31Target: 460Updated: 2012-02-14

Related Papers

Time-Restricted Salutary Effects of Blood Flow Restoration on Venous Thrombosis and Vein Wall Injury in Mouse and Human Subjects
Circulation2021-01-1540 citations
Cost-Effectiveness of Pharmacomechanical Catheter-Directed Thrombolysis Versus Standard Anticoagulation in Patients With Proximal Deep Vein Thrombosis
Circulation Cardiovascular Quality and Outcomes2019-10-0128 citations
Relationships between the use of pharmacomechanical catheter-directed thrombolysis, sonographic findings, and clinical outcomes in patients with acute proximal DVT: Results from the ATTRACT Multicenter Randomized Trial
Vascular Medicine2019-07-2754 citations
Pharmacomechanical Catheter-Directed Thrombolysis in Acute Femoral–Popliteal Deep Vein Thrombosis: Analysis from a Stratified Randomized Trial
Thrombosis and Haemostasis2019-01-3066 citations
Endovascular Thrombus Removal for Acute Iliofemoral Deep Vein Thrombosis
Circulation2019-01-17301 citations
Pharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis.
2017-12-01469 citations