Radiprodil

DRUG7 trials

Conditions

Focal Cortical DysplasiaFocal Cortical Dysplasia (FCD) Type IIGRIN-related DisordersGRIN-related Neurodevelopmental DisorderGRIN-related disorderHepatic ImpairmentInfantile Spasms (IS)Tuberous Sclerosis Complex

Phase 1

Honeycomb: Evaluation of Radiprodil in Children with GRIN-related Disorder

Active, not recruitingNCT05818943

GRIN Therapeutics, Inc.GRIN-related Disorders

Start: 2023-03-07End: 2026-11-30Target: 24Updated: 2024-11-15

A Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effect on Seizures and Behavioral Symptoms of Multiple Individually Titrated Doses of Radiprodil in Children with GRIN-related Disorder (HONEYCOMB)

RecruitingCTIS2023-509672-42-00

Grin Therapeutics Inc.GRIN-related disorder

Start: 2023-02-02Target: 26Updated: 2025-01-28

A Multicenter, Open-label Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effect on Seizures and Behavioral Symptoms of Radiprodil in Patients with Tuberous Sclerosis Complex (TSC) or Focal Cortical Dysplasia (FCD) Type II.

Active, not recruitingCTIS2023-506301-20-00

Grin Therapeutics Inc.Focal Cortical Dysplasia (FCD) Type II, Tuberous Sclerosis Complex (TSC)

Start: 2024-04-15Target: 24Updated: 2025-11-21

Astroscape: A Study of Radiprodil on Safety, Tolerability, Pharmacokinetics, and Effect on Seizures and Behavioral Symptoms in Patients With TSC or FCD Type II

Active, not recruitingNCT06392009

GRIN Therapeutics, Inc.Focal Cortical Dysplasia, Tuberous Sclerosis Complex

Start: 2024-07-10End: 2028-06-01Target: 30Updated: 2026-04-01

Radiprodil in Participants With Hepatic Impairment

RecruitingNCT07457229

GRIN Therapeutics, Inc.Hepatic Impairment

Start: 2026-03-03End: 2027-08-01Target: 40Updated: 2026-05-08

Phase 2

A Phase 2 Study of Radiprodil in Subjects With Drug-resistant Infantile Spasms (IS)

TerminatedNCT02829827

UCB Biopharma S.P.R.L.Infantile Spasms (IS)

Start: 2017-12-04End: 2018-10-02Updated: 2019-09-17

Phase 3

Beeline: A Phase 3 Study in GRIN-related Neurodevelopmental Disorder

RecruitingNCT07224581

GRIN Therapeutics, Inc.GRIN-related Neurodevelopmental Disorder

Start: 2026-01-05End: 2028-07-01Target: 100Updated: 2026-07-17

Related Papers

A pharmacokinetic study of radiprodil oral suspension in healthy adults comparing conventional venous blood sampling with two microsampling techniques.