Radiologic Imaging Procedure

PROCEDURE5 trials

Sponsors

National Cancer Institute (NCI), Jonsson Comprehensive Cancer Center, Children's Oncology Group

Conditions

Anatomic Stage I Breast Cancer AJCC v8Anatomic Stage II Breast Cancer AJCC v8Anatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8Invasive Breast CarcinomaLocalized Estrogen Receptor-Positive Breast CarcinomaLocalized Human Epidermal Growth Factor Receptor (HER2)-Negative Breast CarcinomaLocally Advanced Breast Carcinoma

Phase 1

Testing the Addition of an Anti-Cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (5-Fluorouracil) for Metastatic, Refractory Colorectal Cancer

RecruitingNCT06654037

National Cancer Institute (NCI)Metastatic Microsatellite Stable Colorectal Carcinoma, Refractory Microsatellite Stable Colorectal Carcinoma, Stage IV Colorectal Cancer AJCC v8

Start: 2025-04-18End: 2027-04-01Target: 39Updated: 2026-10-15

Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer

RecruitingNCT07137416

National Cancer Institute (NCI)Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8, Invasive Breast Carcinoma +13

Start: 2026-10-06End: 2028-01-10Target: 36Updated: 2026-10-16

Testing the Combination of Anti-cancer Drugs Actimab-A and Cemiplimab (REGN2810) to Improve Outcomes for Patients With Recurrent Glioblastoma

Not yet recruitingNCT07422363

National Cancer Institute (NCI)Recurrent Glioblastoma, IDH-Wildtype, Recurrent Gliosarcoma, Recurrent WHO Grade 4 Glioma

Start: 2026-12-04End: 2027-02-28Target: 30Updated: 2026-06-12

A Phase 1/2 Study of CBX-12 in Children, Adolescents, or Young Adults With Solid Tumors That Have Come Back After Treatment or Are Difficult to Treat

Not yet recruitingNCT07830667

Children's Oncology GroupRecurrent Childhood Ewing Sarcoma, Recurrent Childhood Malignant Solid Neoplasm, Recurrent Childhood Rhabdomyosarcoma +9

Start: 2027-05-07End: 2033-06-30Target: 79Updated: 2026-09-22

Phase 2

Imlunestrant and Abemaciclib for the Treatment of Estrogen Receptor Positive Breast Cancer in Patients With Minimal Residual Disease, MIRI Trial

RecruitingNCT07191717

Jonsson Comprehensive Cancer CenterAnatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8 +3

Start: 2026-05-18End: 2031-04-30Target: 42Updated: 2026-08-20