RABIPUR®

BIOLOGICAL4 trials

Sponsors

Yisheng Biopharma (Singapore) Pte. Ltd., London School of Hygiene and Tropical Medicine, CureVac

Conditions

Children, OnlyMalaria,FalciparumRabies

Phase 1

Safety and Efficacy of a PIKA Rabies Vaccine Containing the PIKA Adjuvant

CompletedNCT02657161

Yisheng Biopharma (Singapore) Pte. Ltd.Rabies

Start: 2015-02-28End: 2015-07-31Updated: 2016-01-15

A Study to Assess the Safety, Reactogenicity and Immune Response of CureVac's Candidate Rabies mRNA Vaccine in Healthy Adults

CompletedNCT03713086

Start: 2018-10-12End: 2021-11-23Updated: 2024-12-19

Phase 2

Efficacy and Safety of a PIKA Rabies Vaccine Containing the PIKA Adjuvant With an Accelerated Regimen

CompletedNCT02956421

Yisheng Biopharma (Singapore) Pte. Ltd.Rabies

Start: 2016-02-29End: 2016-10-31Updated: 2016-11-08

Phase 3

Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ)

CompletedNCT03143218

London School of Hygiene and Tropical MedicineChildren, Only, Malaria,Falciparum

Start: 2017-04-17End: 2020-03-31Updated: 2022-04-07

Related Papers

The anti-circumsporozoite antibody response to repeated, seasonal booster doses of the malaria vaccine RTS,S/AS01<sub>E</sub>.

2025-02-061 citations

Exploring the host factors affecting asymptomatic Plasmodium falciparum infection: insights from a rural Burkina Faso study.

2023-09-01

The duration of protection against clinical malaria provided by the combination of seasonal RTS,S/AS01E vaccination and seasonal malaria chemoprevention versus either intervention given alone

BMC Medicine2022-10-0729 citations

Impact of seasonal RTS,S/AS01E vaccination plus seasonal malaria chemoprevention on the nutritional status of children in Burkina Faso and Mali

Malaria Journal2022-02-222 citations

The Anti-Circumsporozoite Antibody Response of Children to Seasonal Vaccination With the RTS,S/AS01E Malaria Vaccine

Clinical Infectious Diseases2021-12-109 citations

Seasonal Malaria Vaccination with or without Seasonal Malaria Chemoprevention

New England Journal of Medicine2021-08-25215 citations

Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial.

2021-05-05326 citations

Proof-of-concept of a low-dose unmodified mRNA-based rabies vaccine formulated with lipid nanoparticles in human volunteers: A phase 1 trial.

2021-01-22138 citations

Seasonal malaria vaccination: protocol of a phase 3 trial of seasonal vaccination with the RTS,S/AS01<sub>E</sub>vaccine, seasonal malaria chemoprevention and the combination of vaccination and chemoprevention

BMJ Open2020-09-0116 citations

Evaluation of seasonal malaria chemoprevention in two areas of intense seasonal malaria transmission: Secondary analysis of a household-randomised, placebo-controlled trial in Houndé District, Burkina Faso and Bougouni District, Mali

PLoS Medicine2020-08-2151 citations

A Phase IIa Controlled Human Malaria Infection and Immunogenicity Study of RTS,S/AS01E and RTS,S/AS01B Delayed Fractional Dose Regimens in Malaria-Naive Adults

The Journal of Infectious Diseases2020-07-1744 citations

A phase II randomized study to determine the safety and immunogenicity of the novel PIKA rabies vaccine containing the PIKA adjuvant using an accelerated regimen

Vaccine2017-11-2240 citations

An accelerated rabies vaccine schedule based on toll-like receptor 3 (TLR3) agonist PIKA adjuvant augments rabies virus specific antibody and T cell response in healthy adult volunteers.

2017-01-2225 citations