r-metHuLeptin

DRUG4 trials

Sponsors

Beth Israel Deaconess Medical Center

Conditions

AmenorrheaEnergy Deficiency Due to Short-term FastingFastingHAART-induced Lipodystrophy and Metabolic Syndrome

Phase 1

Pharmacokinetics of Leptin Administration During Fasting

CompletedNCT00140205

Beth Israel Deaconess Medical CenterEnergy Deficiency Due to Short-term Fasting

Start: 2001-02-28End: 2016-12-31Updated: 2018-11-02

Role of Leptin in the Neuroendocrine and Immune Response to Fasting

CompletedNCT00140231

Beth Israel Deaconess Medical CenterFasting

Start: 2002-10-31End: 2016-12-31Updated: 2017-06-07

Phase 2

Study of Leptin for the Treatment of Hypothalamic Amenorrhea

CompletedNCT00130117

Beth Israel Deaconess Medical CenterAmenorrhea

Start: 2010-04-30End: 2016-12-31Updated: 2017-05-17

Randomized, Placebo-Controlled Study of Leptin for the Treatment of HIV Lipodystrophy and Metabolic Syndrome

CompletedNCT00140244

Beth Israel Deaconess Medical CenterHAART-induced Lipodystrophy and Metabolic Syndrome

Start: 2001-12-31End: 2011-06-30Updated: 2017-05-11

Related Papers

PCSK9 and ANGPTL3 levels correlate with hyperlipidemia in HIV-lipoatrophy, are regulated by fasting and are not affected by leptin administered in physiologic or pharmacologic doses.

2022-07-0910 citations

Leptin administered in physiological or pharmacological doses does not regulate circulating angiogenesis factors in humans.

2011-06-1015 citations

Brain responses to food images during the early and late follicular phase of the menstrual cycle in healthy young women: relation to fasting and feeding.

2011-05-1845 citations