R-(-)-gossypol acetic acid

DRUG8 trials

Sponsors

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, National Cancer Institute (NCI), Mayo Clinic

Conditions

Adult Giant Cell GlioblastomaAdult GlioblastomaAdult GliosarcomaAdult Grade III Lymphomatoid GranulomatosisAdult Nasal Type Extranodal NK/T-cell LymphomaBrain and Central Nervous System TumorsContiguous Stage II Adult Burkitt LymphomaContiguous Stage II Adult Diffuse Large Cell Lymphoma

Phase 1

Gossypol (AT-101) and Temozolomide With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

CompletedNCT00390403

Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsBrain and Central Nervous System Tumors

Start: 2007-02-28Target: 50Updated: 2012-05-03

R-(-)-Gossypol Acetic Acid, Cisplatin, and Etoposide in Treating Patients With Advanced Solid Tumors or Extensive Stage Small Cell Lung Cancer

CompletedNCT00544596

National Cancer Institute (NCI)Extensive Stage Small Cell Lung Cancer, Unspecified Adult Solid Tumor, Protocol Specific

Start: 2007-09-30Updated: 2014-04-02

Gossypol, Paclitaxel, and Carboplatin in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

CompletedNCT00891072

National Cancer Institute (NCI)Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma, Contiguous Stage II Adult Burkitt Lymphoma +78

Start: 2009-07-31End: 2011-04-30Updated: 2013-01-10

Lenalidomide and AT-101 in Treating Patients With Relapsed B-Cell Chronic Lymphocytic Leukemia

TerminatedNCT01003769

Mayo ClinicRecurrent Chronic Lymphocytic Leukemia

Start: 2015-07-09End: 2018-12-14Updated: 2020-06-16

Gossypol Acetic Acid With Lenalidomide and Dexamethasone in Treating Patients With Relapsed Symptomatic Multiple Myeloma

CompletedNCT02697344

Mayo ClinicRecurrent Plasma Cell Myeloma

Start: 2016-04-14End: 2023-12-20Updated: 2023-12-28

Phase 2

Gossypol in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme

CompletedNCT00540722

National Cancer Institute (NCI)Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma +1

Start: 2008-01-31End: 2012-06-30Updated: 2017-08-11

R-(-)-Gossypol Acetic Acid in Treating Patients With Recurrent Extensive-Stage Small Cell Lung Cancer

CompletedNCT00773955

National Cancer Institute (NCI)Extensive Stage Small Cell Lung Cancer, Recurrent Small Cell Lung Cancer

Start: 2008-11-30End: 2010-08-31Updated: 2014-05-12

Gossypol Acetic Acid in Treating Patients With Recurrent, Metastatic, or Primary Adrenocortical Cancer That Cannot Be Removed By Surgery

CompletedNCT00848016

National Cancer Institute (NCI)Recurrent Adrenocortical Carcinoma, Stage III Adrenocortical Carcinoma, Stage IV Adrenocortical Carcinoma

Start: 2009-02-28End: 2012-06-30Updated: 2014-05-07

Related Papers

Phase I Study of a Novel Bcl-2 Inhibitor, at-101 in Combination with Lenalidomide and Dexamethasone in Patients with Relapsed and/or Refractory Multiple Myeloma (RRMM)

Blood2019-11-134 citations

A phase I study of AT-101, a BH3 mimetic, in combination with paclitaxel and carboplatin in solid tumors.

2019-08-0622 citations