Pyrotinib Maleate Tablets

DRUG4 trials

Sponsors

West China Hospital, Wuhan University, Tianjin Medical University Cancer Institute and Hospital, Risen (Suzhou) Pharma Tech Co., Ltd.

Conditions

Advanced Solid TumorsBreast CancerCombination ChemotherapyHER2 PositiveHER2+ Advanced Breast Cancer Patients Progressing on TKI Therapy

Phase 1

Pyrotinib Maleate Tablets Combined With Albumin Paclitaxel and Trastuzumab for Her2-positive Breast Cancer

West China HospitalBreast Cancer, Combination Chemotherapy, HER2 Positive

Start: 2019-11-30End: 2021-04-30Target: 20Updated: 2019-11-05

A Clinical Study of JS105 in Combination With Other Anti-tumor Therapies in Patients With Solid Tumors

RecruitingNCT06208410

Risen (Suzhou) Pharma Tech Co., Ltd.Advanced Solid Tumors

Start: 2024-01-11End: 2027-02-26Target: 306Updated: 2025-07-25

Phase 4

Exploratory Study of Neoadjuvant Treatment of HER2-positive Breast Cancer With Py in Combination With HP

Not yet recruitingNCT04929548

Wuhan UniversityBreast Cancer

Start: 2022-01-05End: 2027-09-20Target: 20Updated: 2022-01-05

Unknown Phase

Phase II Clinical Study of T-DM1 and Pyrotinib Maleate in Patients With HER2-positive Metastatic Breast Cancer Who Had Progressed on TKI Therapy

Tianjin Medical University Cancer Institute and HospitalHER2+ Advanced Breast Cancer Patients Progressing on TKI Therapy

Start: 2022-09-30End: 2025-08-23Target: 50Updated: 2022-10-03

Related Papers

Efficacy and safety of pyrotinib combined with trastuzumab emtansine (T-DM1) for patients with advanced HER2-positive breast cancer (BC): A single-arm phase II trial.

Journal of Clinical Oncology2024-06-011 citations

117P Three-year invasive disease-free survival results from a phase II study of pyrotinib plus trastuzumab and albumin-bound paclitaxel as neoadjuvant treatment in HER2-positive early or locally advanced breast cancer

ESMO Open2024-05-01

Neoadjuvant pyrotinib plus trastuzumab and nab-paclitaxel for HER2-positive early or locally advanced breast cancer: an exploratory phase II trial

Gland Surgery2022-01-0118 citations