Pyridostigmine Bromide

DRUG13 trials

Sponsors

Vanderbilt University, NYU Langone Health, Christian Baumann, Centre Hospitalier Régional de la Citadelle, James J. Peters Veterans Affairs Medical Center

Conditions

Autonomic Disturbances in Parkinson's DiseaseAutonomic DysreflexiaAutonomic FailureAutonomic IntegrityBaroreceptor IntegrityBlood PressureCD4+ T LymphocytopeniaCOVID-19

Early Phase 1

A Pilot Study of Pyridostigmine in Pompe Disease

TerminatedNCT02357225

University of FloridaPompe Disease

Start: 2015-08-31End: 2018-01-01Updated: 2018-05-15

Phase 1

Treatment of Orthostatic Hypotension in Autonomic Failure

CompletedNCT00223691

Vanderbilt UniversityAutonomic Failure, Orthostatic Hypotension

Start: 2002-03-31End: 2017-01-31Updated: 2017-01-18

Phase 2

Safety Study of Pyridostigmine in Heart Failure

CompletedNCT01415921

NYU Langone HealthHeart Failure

Start: 2011-10-31End: 2015-07-31Updated: 2017-07-31

Orthostatic Dysregulation and Associated Gastrointestinal Dysfunction in Parkinson's Disease -Treatment

CompletedNCT01993680

Christian BaumannAutonomic Disturbances in Parkinson's Disease

Start: 2012-06-30End: 2016-04-01Updated: 2021-01-25

Safety and Efficacy Study of Pyridostigmine on Patients With Spinal Muscular Atrophy Type 3

CompletedNCT02227823

Centre Hospitalier Régional de la CitadelleSpinal Muscular Atrophy Type 3

Start: 2014-07-31End: 2017-07-31Updated: 2023-10-11

Acetylcholinesterase Inhibition and Orthostatic Hypotension in SCI

CompletedNCT02307526

James J. Peters Veterans Affairs Medical CenterHypotension, Postural

Start: 2011-01-31End: 2015-03-31Updated: 2017-07-21

The Effects of Normalizing Blood Pressure on Cerebral Blood Flow in Hypotensive Individuals With Spinal Cord Injury

CompletedNCT02893553

James J. Peters Veterans Affairs Medical CenterAutonomic Dysreflexia, Autonomic Integrity, Baroreceptor Integrity +7

Start: 2016-12-31End: 2021-12-31Updated: 2024-10-01

Pyridostigmine as Immunomodulator in People Living With HIV

SuspendedNCT03312244

Instituto Nacional de Ciencias Medicas y Nutricion Salvador ZubiranCD4+ T Lymphocytopenia, HIV-1-infection, Immune Deficiency +1

Start: 2019-07-01End: 2022-06-30Target: 60Updated: 2020-04-10

The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome

CompletedNCT03674541

Brigham and Women's HospitalChronic Fatigue Syndrome, Dysautonomia, Exercise Intolerance +6

Start: 2020-01-14End: 2021-12-20Updated: 2022-11-08

Pyridostigmine in Severe SARS-CoV-2 Infection

Instituto Nacional de Ciencias Medicas y Nutricion Salvador ZubiranCOVID-19, SARS-CoV-2

Start: 2020-04-04End: 2021-04-30Target: 436Updated: 2020-07-07

Pyridostigmine Efficacy and Safety for Treatment of Ileus After Colorectal Surgery

RecruitingNCT05334485

Stefan Holubar MD MS FACS, FASCRSPostoperative Ileus

Start: 2024-09-03End: 2026-10-31Target: 50Updated: 2026-01-07

Pyridostigmine for the Treatment of Constipation in Parkinson Disease

RecruitingNCT05603715

University of Vermont Medical CenterConstipation, Parkinson Disease

Start: 2022-08-10End: 2026-12-31Target: 16Updated: 2026-02-23

Phase 4

Treatment and Prognosis of Neurogenic Orthostatic Hypotension : A Prospective Randomized Study

CompletedNCT02308124

Seoul National University HospitalOrthostatic; Hypotension, Neurogenic

Start: 2014-11-30End: 2016-09-30Updated: 2021-10-19

Related Papers

Pharmacodynamics, Safety, and Tolerability of Pyridostigmine Bromide in Heart Failure.

2025-10-31

Clinical Correlates of Efficacy of Pyridostigmine in the Treatment of Orthostatic Hypotension

Hypertension2024-12-275 citations

Neurovascular Dysregulation and Acute Exercise Intolerance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Placebo-Controlled Trial of Pyridostigmine.

2022-05-0628 citations

Predictors of the Pressor Response to the Norepinephrine Transporter Inhibitor, Atomoxetine, in Neurogenic Orthostatic Hypotension

Hypertension2021-06-2822 citations

A parallel-group, multicenter randomized, double-blinded, placebo-controlled, phase 2/3, clinical trial to test the efficacy of pyridostigmine bromide at low doses to reduce mortality or invasive mechanical ventilation in adults with severe SARS-CoV-2 infection: the Pyridostigmine In Severe COvid-19 (PISCO) trial protocol

BMC Infectious Diseases2020-10-1613 citations

Efficacy of single or combined midodrine and pyridostigmine in orthostatic hypotension.

2017-08-0922 citations

Pyridostigmine bromide versus fludrocortisone in the treatment of orthostatic hypotension in Parkinson's disease - a randomized controlled trial.

2017-02-2233 citations

Efficacy of Servo-Controlled Splanchnic Venous Compression in the Treatment of Orthostatic Hypotension

Hypertension2016-06-0776 citations