PVX-410

BIOLOGICAL5 trials

Sponsors

OncoPep, Inc., Massachusetts General Hospital

Conditions

Breast CancerMetastatic Breast CancerMetastatic Triple-Negative Breast CarcinomaSmoldering Multiple MyelomaTriple Negative Breast Cancer

Phase 1

Phase 1/2a Study of Cancer Vaccine to Treat Smoldering Multiple Myeloma

CompletedNCT01718899

OncoPep, Inc.Smoldering Multiple Myeloma

Start: 2012-11-30End: 2016-09-30Updated: 2016-09-28

Adjuvant PVX-410 Vaccine and Durvalumab in Stage II/III Triple Negative Breast Cancer

Active, not recruitingNCT02826434

Massachusetts General HospitalBreast Cancer

Start: 2016-08-18End: 2027-09-30Target: 22Updated: 2025-10-01

A Study of PVX-410, a Cancer Vaccine, and Citarinostat +/- Lenalidomide for Smoldering MM

Active, not recruitingNCT02886065

Massachusetts General HospitalSmoldering Multiple Myeloma

Start: 2017-03-07End: 2026-09-15Updated: 2026-03-13

PVX-410 Vaccine Plus Pembrolizumab in HLA-A2+ Metastatic Triple Negative Breast Cancer

Active, not recruitingNCT03362060

Massachusetts General HospitalMetastatic Breast Cancer, Triple Negative Breast Cancer

Start: 2017-12-12End: 2027-12-30Target: 20Updated: 2026-06-17

Phase 2

Phase 2 Study to Evaluate PVX-410 + Pembrolizumab + Chemotherapy for Metastatic, PD-L1+ Triple-Negative Breast Cancer

OncoPep, Inc.Metastatic Triple-Negative Breast Carcinoma

Start: 2022-04-30End: 2025-04-01Target: 53Updated: 2022-04-20

Related Papers

Abstract P2-14-17: A phase 1b study of PVX-410 vaccine in combination with pembrolizumab in metastatic triple negative breast cancer (mTNBC)

Cancer Research2022-02-156 citations

Assessment of Safety and Immunogenicity of PVX-410 Vaccine With or Without Lenalidomide in Patients With Smoldering Multiple Myeloma

JAMA Oncology2018-08-2182 citations

A phase 1b study of safety and immune response to PVX-410 vaccine alone and in combination with durvalumab (MEDI4736) in HLA-A2+ patients following adjuvant therapy for stage 2/3 triple negative breast cancer.

Journal of Clinical Oncology2017-05-2012 citations