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PV-10 (10% rose bengal disodium)

DRUG4 trials

Sponsors

Provectus Pharmaceuticals, Provectus Biopharmaceuticals, Inc.

Conditions

Approved Alternative TherapyCancer Metastatic to the LiverCutaneous MelanomaCutaneous or Subcutaneous Tumors Where There is no Comparable or SatisfactoryHepatocellular CarcinomaMelanomaMetastatic Breast CancerMetastatic Colon Cancer

Phase 1

A Study to Assess PV-10 Chemoablation of Cancer of the Liver
NCT00986661
Provectus Biopharmaceuticals, Inc.Cancer Metastatic to the Liver, Hepatocellular Carcinoma, Metastatic Breast Cancer +7
Start: 2009-10-31End: 2023-02-28Target: 78Updated: 2022-11-02

Phase 2

Phase 2 Study of Intralesional PV-10 for Metastatic Melanoma
CompletedNCT00521053
Provectus PharmaceuticalsMelanoma
Start: 2007-09-30End: 2012-06-30Updated: 2014-08-25

Phase 3

PV-10 vs Chemotherapy or Oncolytic Viral Therapy for Treatment of Locally Advanced Cutaneous Melanoma
TerminatedNCT02288897
Provectus Biopharmaceuticals, Inc.Cutaneous Melanoma
Start: 2015-04-30End: 2019-09-30Updated: 2022-01-19

Unknown Phase

Expanded Access Protocol for PV-10 for Cutaneous or Subcutaneous Tumors
NCT01260779
Provectus Biopharmaceuticals, Inc.Approved Alternative Therapy, Cutaneous or Subcutaneous Tumors Where There is no Comparable or Satisfactory
Updated: 2016-07-11

Related Papers

Abstract 1121: Identification and <i>in vivo</i> validation of unique anti-oncogenic properties and mechanisms involving protein kinase signalling and autophagy mediated by the investigational new agent PV-10
Cancer Research2022-06-15
Metabolic complete responses (mCR) in patients with metastatic uveal melanoma (mUM) treated with image-guided injection (IGI) of PV-10.
Journal of Clinical Oncology2022-06-012 citations
Pre-clinical evaluation of PV-10 for <i><i>in vitro</i></i> anti-tumor activity in refractory and high-risk adult solid tumors.
Journal of Clinical Oncology2021-05-20
Percutaneous hepatic injection of rose bengal disodium (PV-10) in metastatic uveal melanoma.
Journal of Clinical Oncology2020-05-207 citations
Cohort 1 results of a phase I study of autolytic immunotherapy of metastatic neuroendocrine neoplasms using intralesional rose bengal disodium.
Journal of Clinical Oncology2020-05-201 citations
Intralesional rose bengal for treatment of melanoma.
Journal of Clinical Oncology2016-05-202 citations
Efficacy of intralesional Rose Bengal in patients receiving injection of all existing melanoma in phase II study PV-10-MM-02.
Journal of Clinical Oncology2014-05-209 citations