PULSAR

RADIATION10 trials

Conditions

Biliary Tract CancersBreast Cancer Early Stage Breast Cancer (Stage 1-3)Breast Cancer PatientsCholangiocarcinomaColorectal Cancer (MSI-H)Gastric AdenocarcinomaHR+/HER2- Breast CancerHepatocellular Carcinoma (HCC)

Phase 1

PULSAR Combined With Immunotherapy and Chemotherapy

RecruitingNCT07291947

Wang XinCholangiocarcinoma

Start: 2025-11-04End: 2027-09-10Target: 60Updated: 2025-12-18

NALIRIFOX+Adebrelimab+PULSAR for Advanced Pancreatic Cancer

RecruitingNCT07595172

West China HospitalLocally Advanced and Metastatic Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma (PDAC)

Start: 2026-04-01End: 2029-03-01Target: 55Updated: 2026-05-19

Phase 2

Study of PULSAR-ICI +/- IMSA101 in Patients With Oligoprogressive Solid Tumor Malignancies

TerminatedNCT05846659

ImmuneSensor Therapeutics Inc.Oligoprogressive

Start: 2023-07-07End: 2024-11-20Updated: 2026-05-15

Study of PULSAR-ICI +/- IMSA101 in Patients With Oligometastatic NSCLC and RCC

TerminatedNCT05846646

ImmuneSensor Therapeutics Inc.Oligometastatic Disease

Start: 2023-06-28End: 2024-09-16Updated: 2025-10-20

PD-1 Combined With Chemotherapy and PULSAR in LAPC and Local Recurrence Patients

RecruitingNCT06359275

Fudan UniversityPancreatic Cancer

Start: 2024-06-01End: 2027-10-31Target: 81Updated: 2024-06-25

Hormonal Receptor (HR)-Positive HER2 Negative Breast Cancer Patients Treated With Preoperative ELacestrant and PULSAR Radiotherapy

Not yet recruitingNCT07005882

Azienda Ospedaliero-Universitaria CareggiBreast Cancer Early Stage Breast Cancer (Stage 1-3), Breast Cancer Patients, HR+/HER2- Breast Cancer +1

Start: 2025-09-01End: 2028-03-01Target: 21Updated: 2025-06-05

Neoadjuvant Immunotherapy ± Radiotherapy in MSI-H/dMMR Locally Advanced Colorectal Cancer

Not yet recruitingNCT07403877

Fudan UniversityColorectal Cancer (MSI-H)

Start: 2026-02-01End: 2034-12-31Target: 114Updated: 2026-02-11

PULSAR Combined With Fecal Microbiota Transplantation for Advanced Hepatocellular Carcinoma Progressing After First-Line Targeted-Immunotherapy

RecruitingNCT07463248

Wang XinHepatocellular Carcinoma (HCC)

Start: 2026-04-15End: 2029-01-31Target: 64Updated: 2026-09-02

Anlotinib+Cadonilimab+PULSAR in Advanced Biliary Tract Cancer

Active, not recruitingNCT07635290

West China HospitalBiliary Tract Cancers, Previously Treated, Advanced

Start: 2026-06-03End: 2028-06-30Target: 26Updated: 2026-06-09

Unknown Phase

PULSAR Combined With Immunotherapy for Unresectable Locally Advanced Gastric Cancer

RecruitingNCT07607119

Samsung Medical CenterGastric Adenocarcinoma, Locally Advanced Gastric Cancer, Stomach Neoplasms +1

Start: 2026-05-15End: 2030-04-30Target: 53Updated: 2026-05-28

Related Papers

Abstract PS5-08-01: Hormone receptor (HR)-positive HER2 negative breast cancer patients treated with preoperative Elacestrant and PULSAR adaptive radiotherapy: a phase II study (HELP Trial)

Clinical Cancer Research2026-02-17

Two phase 2A clinical trials to evaluate the safety and efficacy of IMSA101 in combination with radiotherapy and checkpoint inhibitors in oligometastatic and oligoprogressive solid tumor malignancies.