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Pulmonary arterial denervation

PROCEDURE3 trials

Sponsors

Nanjing First Hospital, Nanjing Medical University, Pulnovo Medical (Wuxi) Co., Ltd.

Conditions

Cardiovascular DiseasesHeart FailureHeart Failure With Mid Range Ejection FractionHeart Failure With Preserved Ejection FractionHeart Failure With Reduced Ejection FractionHypertensionObstructive Sleep Apnea SyndromePulmonary Hypertension

Phase 3

A Trial to Evaluate the Safety and Efficacy of Pulmonary Artery Denervation for the Treatment of Pulmonary Hypertension Associated With Left Heart Failure
Active, not recruitingNCT05824923
Pulnovo Medical (Wuxi) Co., Ltd.Cardiovascular Diseases, Heart Failure, Heart Failure With Mid Range Ejection Fraction +5
Start: 2023-08-14End: 2027-02-01Target: 264Updated: 2026-07-21

Unknown Phase

Pulmonary Arterial Denervation in Patients With Pulmonary Hypertension Associated With the Left Heart Failure
CompletedNCT02220335
Nanjing First Hospital, Nanjing Medical UniversityPulmonary Hypertension
Start: 2014-08-08End: 2018-12-30Updated: 2019-07-30
PADN to Treat Severe Obstructive Sleep Apnea
TerminatedNCT02687477
Nanjing First Hospital, Nanjing Medical UniversityObstructive Sleep Apnea Syndrome
Start: 2016-02-29End: 2020-07-21Updated: 2020-07-22

Related Papers

Pulmonary Denervation for Heart Failure–Related Pulmonary Hypertension
New England Journal of Medicine2026-08-30
Pulmonary Artery Denervation for the Treatment of Patients With Pulmonary Hypertension Secondary to Left-Sided Heart Failure: Rationale and Design of the Randomized Controlled PADN-HF-PH Trial
Cardiology Discovery2026-01-08
3-Year Outcome in Patients With Combined Precapillary and Postcapillary Pulmonary Hypertension: Results From PADN-5 Trial.
2023-06-218 citations
Pulmonary Artery Denervation Significantly Increases 6-Min Walk Distance for Patients With Combined Pre- and Post-Capillary Pulmonary Hypertension Associated With Left Heart Failure: The PADN-5 Study.
2018-10-2374 citations