Psilocybin 25 mg

DRUG12 trials

Sponsors

Centre for Addiction and Mental Health, Usona Institute, University of Virginia, NYU Langone Health, University of Calgary

Conditions

Alcohol Use Disorder (AUD)Chronic Low Back Pain (CLBP)Chronic PainDepressive Disorder, MajorIBS - Irritable Bowel SyndromeInvestigating the Importance of the Subjective Psychedelic ExperienceMajor Depressive Disorder (MDD)Methamphetamine Use Disorder

Early Phase 1

Psilocybin for Prolonged Grief Disorder

RecruitingNCT06724289

University of VirginiaProlonged Grief Disorder

Start: 2026-03-01End: 2027-08-01Target: 12Updated: 2026-03-03

Psilocybin-Assisted Psychotherapy in Treating Irritable Bowel Syndrome (IBS)

Not yet recruitingNCT06760533

NYU Langone HealthIBS - Irritable Bowel Syndrome

Start: 2026-08-01End: 2026-12-01Target: 10Updated: 2026-03-05

Psilocybin for Methamphetamine Addiction

RecruitingNCT06899594

Kevin MurnaneMethamphetamine Use Disorder

Start: 2025-04-04End: 2027-03-31Target: 20Updated: 2025-10-07

Phase 2

Does Psilocybin Require Psychedelic Effects to Treat Depression?

RecruitingNCT05710237

Centre for Addiction and Mental HealthTreatment-resistant Depression

Start: 2023-07-01End: 2026-02-28Target: 60Updated: 2025-04-25

Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST)

RecruitingNCT06512220

Centre for Addiction and Mental HealthTreatment Resistant Depression

Start: 2025-04-21End: 2027-09-30Target: 12Updated: 2025-05-04

Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)

RecruitingNCT06518720

Centre for Addiction and Mental HealthChronic Pain, Treatment Resistant Depression

Start: 2025-04-01End: 2027-12-31Target: 16Updated: 2025-04-25

Subjective Experience Following Psilocybin

Not yet recruitingNCT06768944

University of CalgaryInvestigating the Importance of the Subjective Psychedelic Experience

Start: 2026-04-01End: 2028-01-01Target: 128Updated: 2026-02-06

Psilocybin With Psychological Support (Psi-PS) for Military Veterans and First Responders With Co-occurring PTSD & Alcohol Use Disorder (AUD)

RecruitingNCT06853912

Nathan Brashares SackettAlcohol Use Disorder (AUD), PTSD

Start: 2025-06-01End: 2026-06-01Target: 40Updated: 2025-08-28

Psilocybin-Assisted Therapy for Sexual Assault-Related PTSD

Not yet recruitingNCT06902974

Sunstone MedicalPost Traumatic Stress Disorder, PTSD

Start: 2025-12-31End: 2027-10-31Target: 35Updated: 2025-11-25

Psilocybin-Assisted Physical Therapy in Chronic Low Back Pain

Not yet recruitingNCT07306364

Yale UniversityChronic Low Back Pain (CLBP), Physical Therapy, Psilocybin

Start: 2026-06-30End: 2029-06-30Target: 45Updated: 2025-12-29

Psilocybin-assisted Therapy for Comorbid Major Depressive Disorder and Alcohol Use Disorder

Not yet recruitingNCT07405606

Centre for Addiction and Mental HealthAlcohol Use Disorder (AUD), Major Depressive Disorder (MDD)

Start: 2026-03-01End: 2028-06-01Target: 30Updated: 2026-02-12

Phase 3

Psilocybin for Major Depressive Disorder (MDD)

Active, not recruitingNCT06308653

Usona InstituteDepressive Disorder, Major

Start: 2024-03-13End: 2026-12-30Target: 240Updated: 2025-12-15