Psilocybin (high dose)

DRUG4 trials

Sponsors

Brugmann University Hospital, University of Pennsylvania, Johns Hopkins University, Centre Hospitalier Universitaire de Nīmes

Conditions

Alcohol Use DisorderDepressive SympotomsMusic InterventionOpioid Use DisorderPsilocybinSevere Alcohol Use Disorder

Phase 1

PRoMiSS: Psilocybin and the Role of Music in Set and Setting

RecruitingNCT07180108

Johns Hopkins UniversityMusic Intervention, Psilocybin

Start: 2025-08-12End: 2028-08-01Target: 100Updated: 2026-09-15

Phase 2

Psilocybin-Assisted Therapy for Severe Alcohol Use Disorder

RecruitingNCT06160232

Brugmann University HospitalSevere Alcohol Use Disorder

Start: 2024-02-15End: 2026-06-15Target: 62Updated: 2024-08-07

Psilocybin on Brain Mechanisms of Motivation in OUD

RecruitingNCT06810310

University of PennsylvaniaOpioid Use Disorder

Start: 2025-12-22End: 2027-05-01Target: 24Updated: 2026-07-09

Phase 3

Efficacy in Relapse Prevention: Psilocybin in Alcohol Use Disorder With Depressive Symptoms

RecruitingNCT07638553

Centre Hospitalier Universitaire de NīmesAlcohol Use Disorder, Depressive Sympotoms, Psilocybin

Start: 2026-06-30End: 2030-06-01Target: 172Updated: 2026-07-01

Related Papers

Psilocybin-assisted therapy for severe alcohol use disorder: protocol for a double-blind, randomized, placebo-controlled, 7-month parallel-group phase II superiority trial.

2024-01-265 citations