Proton craniospinal irradiation (CSI)

RADIATION2 trials

Sponsors

Memorial Sloan Kettering Cancer Center

Conditions

Leptomeningeal Metastases

Phase 1

Study of Proton Radiation to the Brain and Spinal Cord for Patients With Leptomeningeal Metastases

CompletedNCT03520504

Memorial Sloan Kettering Cancer CenterLeptomeningeal Metastases

Start: 2018-04-26End: 2022-12-22Updated: 2022-12-23

Phase 2

Proton Craniospinal Radiation Therapy vs. Partial Photon Radiation Therapy for Leptomeningeal Metastasis From Solid Tumors

CompletedNCT04343573

Memorial Sloan Kettering Cancer CenterLeptomeningeal Metastases

Start: 2020-04-10End: 2026-02-25Updated: 2026-02-27

Related Papers

Proton Craniospinal Irradiation for Patients With Leptomeningeal Metastasis: A Randomized Clinical Trial.

2025-11-011 citations

OS10.4.A CXCL1 MEDIATES LEPTOMENINGEAL METASTASIS GROWTH

Neuro-Oncology2024-10-01

Phase II randomized study comparing proton craniospinal irradiation with photon involved-field radiotherapy for patients with solid tumor leptomeningeal metastasis.

Journal of Clinical Oncology2022-06-013 citations

Long-Term Outcomes of a Prospective Clinical Trial of Proton Craniospinal Irradiation for Leptomeningeal Metastasis.

2021-11-01

CMET-21. A PHASE IB STUDY OF PROTON CRANIOSPINAL IRRADIATION FOR THE TREATMENT OF SOLID TUMOR LEPTOMENINGEAL METASTASES

Neuro-Oncology2019-11-01