Proton Beam Craniospinal Irradiation

RADIATION2 trials

Sponsors

NRG Oncology, University of Washington

Conditions

Anatomic Stage IV Breast Cancer AJCC v8Metastatic Breast CarcinomaMetastatic Lung Non-Small Cell CarcinomaMetastatic Malignant Neoplasm in the LeptomeningesStage IV Lung Cancer AJCC v8

Phase 2

Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer

RecruitingNCT06518057

University of WashingtonAnatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic Lung Non-Small Cell Carcinoma +2

Start: 2025-03-03End: 2027-12-30Target: 22Updated: 2025-12-11

Phase 3

Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

RecruitingNCT06500481

NRG OncologyAnatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic Lung Non-Small Cell Carcinoma +2

Start: 2025-03-04End: 2028-07-31Target: 115Updated: 2026-04-03

Related Papers

OGCT-05 A MULTI-CENTER PHASE II TRIAL OF HIPPOCAMPAL AVOIDANCE IN CRANIOSPINAL IRRADIATION FOR LEPTOMENINGEAL METASTASES FROM SOLID TUMORS

Neuro-Oncology Advances2025-08-01